Engineered extracellular vesicles for tissue repair and regeneration.

IF 6.3 1区医学 Q1 DERMATOLOGY

Burns & Trauma Pub Date : 2024-10-22 DOI:10.1093/burnst/tkae062

Yan Zhang,Dan Wu,Chen Zhou,Muran Bai,Yucheng Wan,Qing Zheng,Zhijin Fan,Xianwen Wang,Chun Yang

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引用次数: 0

Abstract

Extracellular vesicles (EVs) are heterogeneous membrane-like vesicles secreted by living cells that are involved in many physiological and pathological processes and act as intermediaries of intercellular communication and molecular transfer. Recent studies have shown that EVs from specific sources regulate tissue repair and regeneration by delivering proteins, lipids, and nucleic acids to target cells as signaling molecules. Nanotechnology breakthroughs have facilitated the development and exploration of engineered EVs for tissue repair. Enhancements through gene editing, surface modification, and content modification have further improved their therapeutic efficacy. This review summarizes the potential of EVs in tissue repair and regeneration, their mechanisms of action, and their research progress in regenerative medicine. This review highlights their design logic through typical examples and explores the development prospects of EVs in tissue repair. The aim of this review is to provide new insights into the design of EVs for tissue repair and regeneration applications, thereby expanding their use in regenerative medicine.

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用于组织修复和再生的工程细胞外囊泡。

细胞外囊泡（EVs）是活细胞分泌的异质性膜状囊泡，参与许多生理和病理过程，是细胞间通信和分子传递的中介。最近的研究表明，来自特定来源的 EVs 可将蛋白质、脂类和核酸作为信号分子输送到靶细胞，从而调节组织的修复和再生。纳米技术的突破促进了用于组织修复的工程电动体的开发和探索。通过基因编辑、表面改性和内容改性等方法对其进行增强，进一步提高了其治疗效果。本综述总结了 EVs 在组织修复和再生中的潜力、作用机制以及在再生医学中的研究进展。本综述通过典型实例强调了 EVs 的设计逻辑，并探讨了 EVs 在组织修复中的发展前景。本综述旨在为组织修复和再生应用中的 EVs 设计提供新的见解，从而扩大 EVs 在再生医学中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Burns & Trauma 医学-皮肤病学

CiteScore

8.40

自引率

9.40%

发文量

186

审稿时长

6 weeks

期刊介绍： The first open access journal in the field of burns and trauma injury in the Asia-Pacific region, Burns & Trauma publishes the latest developments in basic, clinical and translational research in the field. With a special focus on prevention, clinical treatment and basic research, the journal welcomes submissions in various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, and the prevention and regeneration of burns and trauma injuries. With an expert Editorial Board and a team of dedicated scientific editors, the journal enjoys a large readership and is supported by Southwest Hospital, which covers authors'' article processing charges.