The Alzheimer's Disease Neuroimaging Initiative-4 (ADNI-4) Engagement Core: A culturally informed, community-engaged research (CI-CER) model to advance brain health equity

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2024-10-23 DOI:10.1002/alz.14242

Mónica Rivera Mindt, Alyssa Arentoft, Amanda T. Calcetas, Vanessa A. Guzman, Hannatu Amaza, Adeyinka Ajayi, Miriam T. Ashford, Omobolanle Ayo, Lisa L. Barnes, Alicia Camuy, Catherine Conti, Adam Diaz, Bashir Easter, David J. Gonzalez, Yolanda Graham Dotson, Isabella Hoang, Kaori Kubo Germano, Gladys E. Maestre, Fabiola Magaña, Oanh L. Meyer, Melanie J. Miller, Rachel Nosheny, Van M. Ta Park, Shaniya Parkins, Lisa Renier Thomas, Joe Strong, Sandra Talavera, Steven P. Verney, Trinity Weisensel, Michael W. Weiner, Ozioma C. Okonkwo, the Alzheimer's Disease Neuroimaging Initiative

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引用次数: 0

Abstract

INTRODUCTION

The Alzheimer's Disease Neuroimaging Initiative-4 (ADNI-4) Engagement Core was launched to advance Alzheimer's disease (AD) and AD-related dementia (ADRD) health equity research in underrepresented populations (URPs). We describe our evidence-based, scalable culturally informed, community-engaged research (CI-CER) model and demonstrate its preliminary success in increasing URP enrollment.

METHODS

URPs include ethnoculturally minoritized, lower education (≤ 12 years), and rural populations. The CI-CER model includes: (1) culturally informed methodology (e.g., less restrictive inclusion/exclusion criteria, sociocultural measures, financial compensation, results disclosure, Spanish Language Capacity Workgroup) and (2) inclusive engagement methods (e.g., the Engagement Core team; Hub Sites; Community–Science Partnership Board).

RESULTS

As of April 2024, 60% of ADNI-4 new in-clinic enrollees were from ethnoculturally or educationally URPs. This exceeds ADNI-4's ≥ 50% URP representation goal for new enrollees but may not represent final enrollment.

DISCUSSION

Findings show a CI-CER model increases URP enrollment in AD/ADRD clinical research and has important implications for clinical trials to advance health equity.

Highlights

The Alzheimer's Disease Neuroimaging Initiative-4 (ADNI-4) uses a culturally informed, community-engaged research (CI-CER) approach.
The CI-CER approach is scalable and sustainable for broad, multisite implementation.
ADNI-4 is currently exceeding its inclusion goals for underrepresented populations.

Abstract Image

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阿尔茨海默氏症神经成像计划-4（ADNI-4）参与核心：文化信息、社区参与研究（CI-CER）模式，促进脑健康公平。

导言阿尔茨海默病神经影像计划-4（ADNI-4）参与核心旨在推动代表性不足人群（URPs）中的阿尔茨海默病（AD）和AD相关痴呆（ADRD）健康公平研究。我们介绍了以证据为基础、可扩展的文化信息、社区参与研究（CI-CER）模式，并展示了该模式在增加 URP 注册人数方面取得的初步成功。CI-CER 模式包括(结果截至 2024 年 4 月，60% 的 ADNI-4 诊所内新注册者来自民族文化或教育程度较低的 URPs。讨论研究结果表明，CI-CER 模式提高了老年痴呆症/ADRD 临床研究中 URP 的参与率，对临床试验促进健康公平具有重要意义。CI-CER 方法具有可扩展性和可持续性，适用于广泛的多站点实施。ADNI-4 目前正在超额完成对代表性不足人群的纳入目标。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.