Increasing prevalence of galactose-α-1,3-galactose sensitization in the Danish general adult population.

IF 12.6 1区医学 Q1 ALLERGY

Allergy Pub Date : 2024-10-23 DOI:10.1111/all.16360

Katja Biering Leth-Møller,Marianne van Hage,Danijela Apostolovic,Jennifer Astrup Sørensen,Christian Vestergaard,Flemming Madsen,Lene Jung Kjær,Torben Hansen,Anna Jonsson,Simon Francis Thomsen,Allan Linneberg

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引用次数: 0

Abstract

BACKGROUND Alpha-gal syndrome is a novel food allergy to the oligosaccharide galactose-α-1,3-galactose (alpha-gal) present in mammalian meat. Tick bites are considered an important route of sensitization to alpha-gal. Data on alpha-gal sensitization in the general population is scant. We utilized a unique data source of repeated population-based health examination studies to assess prevalence, time trends, risk factors, and characteristics of alpha-gal sensitization. METHODS Alpha-gal sensitization was assessed in >11.000 adults from four health examination studies of randomly invited residents in the Copenhagen region conducted in 1990-1991, 2011-2012, 2012-2015, and 2016-2017. Alpha-gal sensitization was defined as serum specific IgE (sIgE) to alpha-gal ≥0.1 kUA/L; ≥0.35 kUA/L; ≥0.7 kUA/L; ≥3.5 kUA/L. The population was characterized according to genetically determined ABO blood group, aeroallergen sensitization, and pets at home. RESULTS The prevalence of sIgE to alpha-gal ≥0.1 kUA/L was 1.3% in 1990-1991, 3.7% in 2012-2015 and 3.2% in 2016-2017. Of those sensitized to alpha-gal >97% reported to consume red meat at least once a week, even for sIgE to alpha-gal ≥3.5 kUA/L. Male sex, older age, aeroallergen sensitization, cat at home, and blood group A were associated with increased odds of alpha-gal sensitization. The known protective effect of blood group B was confirmed. CONCLUSION In this general adult population, the prevalence of alpha-gal sensitization had doubled from 1990-1991 to 2016-2017. This could potentially be due to increased tick exposure and an increased atopic predisposition.

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丹麦普通成年人中半乳糖-α-1,3-半乳糖过敏症的发病率越来越高。

背景α-gal 综合征是对哺乳动物肉类中的低聚糖-α-1,3-半乳糖（α-gal）的一种新型食物过敏症。蜱虫叮咬被认为是对α-gal过敏的一个重要途径，但有关普通人群对α-gal过敏的数据却很少。我们利用基于人口的重复健康检查研究这一独特的数据来源，评估了α-gal致敏的流行率、时间趋势、风险因素和特征。方法1990-1991年、2011-2012年、2012-2015年和2016-2017年对哥本哈根地区随机邀请的居民进行了四次健康检查研究，对超过11000名成年人进行了α-gal致敏评估。α-gal致敏定义为血清中α-gal特异性IgE（sIgE）≥0.1 kUA/L；≥0.35 kUA/L；≥0.7 kUA/L；≥3.5 kUA/L。结果1990-1991年，α-gal的sIgE≥0.1 kUA/L的患病率为1.3%，2012-2015年为3.7%，2016-2017年为3.2%。在对α-gal过敏的人群中，>97%的人表示每周至少食用一次红肉，即使对α-gal的sIgE≥3.5 kUA/L也是如此。男性、高龄、航空过敏原致敏、家中养猫和血型 A 与α-gal 致敏几率增加有关。结论在这一普通成年人群中，α-gal致敏率从1990-1991年到2016-2017年翻了一番。这可能是由于蜱虫暴露增加和特应性倾向增加所致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergy 医学-过敏

CiteScore

26.10

自引率

9.70%

发文量

393

审稿时长

2 months

期刊介绍： Allergy is an international and multidisciplinary journal that aims to advance, impact, and communicate all aspects of the discipline of Allergy/Immunology. It publishes original articles, reviews, position papers, guidelines, editorials, news and commentaries, letters to the editors, and correspondences. The journal accepts articles based on their scientific merit and quality. Allergy seeks to maintain contact between basic and clinical Allergy/Immunology and encourages contributions from contributors and readers from all countries. In addition to its publication, Allergy also provides abstracting and indexing information. Some of the databases that include Allergy abstracts are Abstracts on Hygiene & Communicable Disease, Academic Search Alumni Edition, AgBiotech News & Information, AGRICOLA Database, Biological Abstracts, PubMed Dietary Supplement Subset, and Global Health, among others.