Rheumatic diseases detected in patients presenting with uveitis.

Northern clinics of Istanbul Pub Date : 2024-10-01 eCollection Date: 2024-01-01 DOI:10.14744/nci.2023.14564
Esin Ozturk, Tuba Yuce Inel, Mahmut Kaya, Gercek Sen
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Abstract

Objective: Uveitis may occur in the course of systemic inflammatory rheumatic diseases (IRD), or it may be the first clinical manifestation of these diseases. The aim of this study was to determine the incidence of IRD in patients whose initial clinical manifestation was non-infectious uveitis.

Methods: The study included adult patients diagnosed as having noninfectious uveitis in the department of ophthalmology and referred to rheumatology for further investigation of potential rheumatic diseases as underlying etiology of uveitis. The patients' demographic and clinical features, laboratory, and imaging findings were examined.

Results: One hundred six patients who were diagnosed as having uveitis (42.4% anterior, 2.8% intermediate, 19.8% posterior, and 34.9% panuveitis) were included. Just over half (52.8%) of the patients were male and the mean age was 40.1±14.8 years. The mean age at the uveitis attack was 38.7±15 years. One-third (33%) of the patients were diagnosed as having rheumatologic disease (spondyloarthritis (SpA) n=10, Behcet disease (BD) n=17, vasculitides n=2, sarcoidosis n=2, undifferentiated connective tissue diseases n=3, rheumatoid arthritis n=1). SpA was diagnosed in 20% of patients presenting with anterior uveitis. BD was detected in 27% of patients referred with panuveitis and in 33.3% of patients whose first clinical finding was posterior segment involvement. Bilateral uveitis was detected in two-thirds of patients with posterior uveitis and tended to recur more frequently (p=0.014).

Conclusion: Rheumatic diseases have been identified in approximately one-third of patients presenting with different types of uveitis. Investigations addressing systemic rheumatic diseases are of paramount importance in patients with uveitis because they may change diagnosis and treatment processes.

在葡萄膜炎患者中发现风湿病。
目的:葡萄膜炎可能发生在全身性炎症性风湿病(IRD)的病程中,也可能是这些疾病的首发临床表现。本研究旨在确定最初临床表现为非感染性葡萄膜炎的患者中 IRD 的发病率:研究对象包括在眼科确诊为非感染性葡萄膜炎并转诊至风湿免疫科进一步检查葡萄膜炎潜在病因风湿病的成年患者。对患者的人口统计学特征、临床特征、实验室和影像学检查结果进行了研究:共纳入了 16 名被诊断为葡萄膜炎的患者(42.4% 前葡萄膜炎、2.8% 中葡萄膜炎、19.8% 后葡萄膜炎和 34.9% 泛葡萄膜炎)。一半以上(52.8%)的患者为男性,平均年龄为 40.1±14.8 岁。葡萄膜炎发作时的平均年龄为 38.7±15 岁。三分之一(33%)的患者被诊断为患有风湿病(脊柱关节炎(SpA)10 人,白塞病(BD)17 人,血管炎 2 人,类肉瘤病 2 人,未分化结缔组织病 3 人,类风湿性关节炎 1 人)。20%的前葡萄膜炎患者被诊断为SpA。27%的泛葡萄膜炎转诊患者和33.3%首次临床发现后节受累的患者被检测出患有BD。三分之二的后葡萄膜炎患者被检测出患有双侧葡萄膜炎,且复发率较高(P=0.014):结论:在出现不同类型葡萄膜炎的患者中,约有三分之一被查出患有风湿病。对葡萄膜炎患者进行全身风湿病检查至关重要,因为这可能会改变诊断和治疗过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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