Piperonylic Acid Promotes Hair Growth by Activation of EGFR and Wnt/β-Catenin Pathway.

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2024-10-07 DOI:10.3390/ijms251910774

Seung Hyun Han, Kyung Won Jo, Younghyun Kim, Kyong-Tai Kim

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引用次数: 0

Abstract

Dermal papilla cells (DPCs) are located at the bottom of the hair follicle and play a critical role in hair growth, shape, and cycle. Epidermal growth factor receptor (EGFR) and Wnt/β-catenin signaling pathways are essential in promoting keratinocyte activation as well as hair follicle formation in DPCs. Piperonylic acid is a small molecule that induces EGFR activation in keratinocytes. However, the effects of piperonylic acid on DPCs in regard to the stimulation of hair growth have not been studied. In the present study, piperonylic acid was shown to activate the Wnt/β-catenin signaling pathway in addition to the EGFR signaling pathway in DPCs. Piperonylic acid suppressed DKK1 expression, which presumably promoted the accumulation of β-catenin in the nucleus. In addition, piperonylic acid promoted cyclin D upregulation and cell growth and increased the expression of alkaline phosphatase (ALP), a DPC marker. In a clinical study, the group that applied a formulation containing piperonylic acid had a significantly higher number of hairs per unit area than the placebo group. These results identify piperonylic acid as a promising new candidate for hair loss treatment.

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胡椒酸通过激活表皮生长因子受体和 Wnt/β-Catenin 通路促进毛发生长

真皮乳头细胞（DPCs）位于毛囊底部，在毛发的生长、形状和周期中起着至关重要的作用。表皮生长因子受体（EGFR）和 Wnt/β-catenin 信号通路对促进角质形成细胞的活化以及 DPCs 中毛囊的形成至关重要。胡椒酸是一种能诱导角质形成细胞中表皮生长因子受体活化的小分子。然而，有关胡椒酸在刺激毛发生长方面对 DPCs 的影响尚未进行研究。在本研究中，除表皮生长因子受体信号通路外，胡椒酸还能激活 DPCs 中的 Wnt/β-catenin 信号通路。胡椒酸抑制了 DKK1 的表达，这可能促进了 β-catenin 在细胞核中的积累。此外，胡椒酸还能促进细胞周期蛋白 D 的上调和细胞生长，并增加 DPC 标志物碱性磷酸酶（ALP）的表达。在一项临床研究中，施用含有胡椒酸配方的组别单位面积上的毛发数量明显高于安慰剂组别。这些结果表明，胡椒酸是一种很有前景的脱发治疗新候选药物。

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来源期刊

International Journal of Molecular Sciences 化学-化学综合

自引率

10.70%

发文量

13472

审稿时长

1.7 months

期刊介绍： The International Journal of Molecular Sciences (ISSN 1422-0067) provides an advanced forum for chemistry, molecular physics (chemical physics and physical chemistry) and molecular biology. It publishes research articles, reviews, communications and short notes. Our aim is to encourage scientists to publish their theoretical and experimental results in as much detail as possible. Therefore, there is no restriction on the length of the papers or the number of electronics supplementary files. For articles with computational results, the full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material (including animated pictures, videos, interactive Excel sheets, software executables and others).