Common viral respiratory infections in children with cancer during the COVID-19 pandemic: a multicenter study from Türkiye.

Dilek Kaçar, Rejin Kebudi, Derya Özyörük, Deniz Tuğcu, Ayşenur Bahadır, Zeynep Canan Özdemir, Ali Aykan Özgüven, Mehmet Fatih Orhan, Ayşen Türedi Yıldırım, Canan Albayrak, İbrahim Kartal, Neriman Sarı, Hüseyin Tokgöz, Meryem Albayrak, Aylin Canbolat Ayhan, Nilgün Eroğlu, Sultan Aydın, Veysiye Hülya Üzel, Bülent Zülfikar, Ülkü Miray Yıldırım, Mustafa Büyükavcı, Hüseyin Gülen, Ersin Töret, Özcan Bör, Namık Yaşar Özbek, İnci Ergürhan İlhan, Neşe Yaralı
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Abstract

Background: Microbiologic confirmation of respiratory tract infections gained importance during the coronavirus disease 2019 (COVID-19) pandemic. This study retrospectively evaluated seasonal distribution, clinical presentation, and complications of respiratory viral infections (RVIs) other than COVID-19 in children with cancer during and after the pandemic lockdown.

Methods: Two hundred and sixty-five inpatient and outpatient RVI episodes in 219 pediatric cancer patients confirmed by multiplex reverse transcriptase polymerase chain reaction (RT-PCR) panels from 13 centers were enrolled.

Results: Eighty-six (32.5%) of the total 265 episodes occurred in 16 months corresponding to the lockdowns in Türkiye, and the remaining 67.5% in 10 months thereafter. Human rhinovirus/enterovirus (hRE) (48.3%) was the most common agent detected during and after lockdown. Parainfluenza virus (PIV) (23.0%), influenza virus (9.8%), and respiratory syncytial virus (RSV) (9.1%) were the other common agents. The 28.7% of episodes were lower respiratory tract infections (LRTIs), and complications and mortality were higher than upper respiratory tract infections (URTIs) (25.0% vs 5.3%). Bacteremia was identified in 11.5% of culture-drawn episodes. Treatment delay in one-third and death within four weeks after RVI in 4.9% of episodes were observed.

Conclusion: During the pandemic, fewer episodes of RVIs occurred during the lockdown period. Respiratory viruses may cause complications, delays in treatment, and even death in children with cancer. Therefore, increased awareness of RVIs and rapid detection of respiratory viruses will benefit the prevention and, in some cases, abrupt supportive and some antiviral treatment of RVI in children with cancer.

COVID-19 大流行期间癌症患儿的常见呼吸道病毒感染:来自土耳其的一项多中心研究。
背景:在2019年冠状病毒病(COVID-19)大流行期间,呼吸道感染的微生物学确认变得越来越重要。本研究回顾性评估了大流行封锁期间和之后癌症患儿除 COVID-19 以外的呼吸道病毒感染(RVI)的季节性分布、临床表现和并发症:方法:对 13 个中心的 219 名儿科癌症患者中经多重逆转录酶聚合酶链反应(RT-PCR)面板确认的 265 例住院和门诊 RVI 病例进行了登记:结果:在总共 265 例病例中,有 86 例(32.5%)发生在土耳其封锁的 16 个月内,其余 67.5%发生在此后的 10 个月内。人鼻病毒/肠道病毒(hRE)(48.3%)是封锁期间和封锁后检测到的最常见病原体。其他常见病原体包括副流感病毒(PIV)(23.0%)、流感病毒(9.8%)和呼吸道合胞病毒(RSV)(9.1%)。28.7%的病例为下呼吸道感染(LRTI),并发症和死亡率高于上呼吸道感染(URTI)(25.0% 对 5.3%)。在 11.5% 的培养抽取病例中发现了菌血症。三分之一的病例延误了治疗,4.9%的病例在 RVI 后四周内死亡:结论:在大流行期间,封锁期间发生的 RVI 病例较少。呼吸道病毒可能导致癌症患儿出现并发症、治疗延误甚至死亡。因此,提高对 RVI 的认识和快速检测呼吸道病毒将有利于预防癌症患儿的 RVI,并在某些情况下对 RVI 进行突然的支持性治疗和一些抗病毒治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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