The relationship between the degree of visceral pleural invasion and survival in non-small cell lung cancer.

Northern clinics of Istanbul Pub Date : 2024-09-12 eCollection Date: 2024-01-01 DOI:10.14744/nci.2023.25349
Seyma Ozden, Isil Gokdemir, Murat Kiyik
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Abstract

Objective: The aim of this study was to evaluate the relationship between the degree of visceral pleural invasion (VPI) and survival in patients operated for non-small cell lung cancer (NSCLC).

Methods: Between 2013 and 2015, 202 patients who were diagnosed with NSCLC in our center and followed up in our clinic were retrospectively evaluated. To examine the preoperative and postoperative prognostic factors of the patients, postoperative pathology results, demographic data and data on recurrence status were obtained from our hospital database and patient files.

Results: VPI Survival analysis was performed by dividing 3 groups: PL0, PL1 and PL2. Mean survival (MS) was calculated as 39.528±1.469 (36.655-42.402; 95% CI) months for PL0, 35.136±3.115 (29.031-41.240; 95% CI) months for PL1, and 24.688±3.697 (17.441-31.934; 95% CI) for PL2 (p=0.020). When we consider PL0 and PL1 as a single group and compare it with PL2, the MS time of the PL0-PL1 group was 38.358±1.346 (35.721-40.995; 95% CI) months, while the MS time of the PL2 group was 24.688±3.697 (17.441-31.934; 95% CI) months (p=0.020).

Conclusion: Although PL0, PL1 and PL2 were classified into a single group (all considered as T2), this study showed that the presence of PL2 was associated with a poor prognosis in terms of survival, independent of lymph node involvement, histopathological subtype of the tumor and tumor size.

非小细胞肺癌内脏胸膜侵犯程度与存活率之间的关系。
研究目的本研究旨在评估非小细胞肺癌(NSCLC)手术患者内脏胸膜侵犯(VPI)程度与生存期之间的关系:方法:回顾性评估2013年至2015年间在本中心确诊并在本诊所随访的202例非小细胞肺癌患者。为了研究患者的术前和术后预后因素,我们从医院数据库和患者档案中获取了术后病理结果、人口统计学数据和复发状况数据:VPI 生存分析分为三组:PL0、PL1 和 PL2:PL0、PL1 和 PL2。PL0的平均生存期(MS)为39.528±1.469(36.655-42.402;95% CI)个月,PL1为35.136±3.115(29.031-41.240;95% CI)个月,PL2为24.688±3.697(17.441-31.934;95% CI)个月(P=0.020)。当我们将 PL0 和 PL1 视为一组并与 PL2 进行比较时,PL0-PL1 组的 MS 时间为(38.358±1.346)个月(35.721-40.995;95% CI),而 PL2 组的 MS 时间为(24.688±3.697)个月(17.441-31.934;95% CI)(P=0.020):虽然PL0、PL1和PL2被归为一组(均被视为T2),但本研究表明,PL2的存在与预后不良的生存率有关,与淋巴结受累、肿瘤组织病理学亚型和肿瘤大小无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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