Microarchitectural properties of compacted cancellous bone allografts: A morphology micro-computed tomography analysis

IF 3.3 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-10-15 DOI:10.1016/j.jmbbm.2024.106781

D. Putzer , J. Pallua , G. Degenhardt , D. Dammerer , M. Nogler , R. Arora

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Abstract

Massive bone loss poses a significant challenge in defect reconstruction. The use of compacted allografts is a valuable technique to reconstruct bone stock. This study aimed to assess the impact of compression on the microstructure of native cancellous bone chips with a micro-CT analysis.

Bone samples were harvested from 15 femoral heads donated by patients who underwent total hip arthroplasty. Bone chips were prepared using a bone mill. All samples with the same weight were compressed by 25% and 50% of their original volume and subsequently scanned with a micro-CT scanner to determine the microarchitectural morphology of the bone chips. Uniaxial compression test was carried out before and after a standardized compaction procedure.

Comparing the samples without compaction to 50%, the number of trabeculae doubled, the volume ratio doubled, and the trabeculae spacing was reduced, showing voids of 800 μm on average. The number of interlocking possibilities tripled, while no differences were seen in the trabeculae morphology. Uniaxial compression test showed a yield limit after compaction of 0.125 MPa.

Interlocking might occur three times more with a denser material than in a non-compacted sample. The increase in density comparable to manual intraoperative compaction did not lead to significant fragmentation of the allograft material. The assessed microarchitecture should, therefore, reassemble the intraoperative situation during a manual bone impaction procedure.

查看原文本刊更多论文

压实松质骨异体移植物的微结构特性：形态学微型计算机断层扫描分析。

大量骨质流失给缺损重建带来了巨大挑战。使用压缩同种异体骨是重建骨量的一项重要技术。本研究旨在通过显微 CT 分析评估压缩对原生松质骨片微观结构的影响。骨样本取自接受全髋关节置换术的患者捐赠的 15 个股骨头。使用骨研磨机制备骨片。将重量相同的所有样本分别压缩其原始体积的 25% 和 50%，然后用显微 CT 扫描仪进行扫描，以确定骨片的微观结构形态。在标准化压实程序前后进行了单轴压缩测试。与未压实至 50%的样品相比，骨小梁数量增加了一倍，体积比增加了一倍，骨小梁间距减小，平均空隙为 800 μm。交错可能性的数量增加了两倍，而小梁的形态却没有变化。单轴压缩试验显示，压实后的屈服极限为 0.125 兆帕。与未经压实的样品相比，密度更大的材料发生交错的可能性要高出三倍。与术中人工压实相当的密度增加并不会导致同种异体移植材料明显破碎。因此，所评估的微观结构应能重现人工骨压实过程中的术中情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.