Relationship of Serum Nesfatin-1 and Insulin-Like Growth Factor-1 Levels with Adverse Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome.

Yanyan Wang, Rui Li, Binzhou Sun, Weifu Song, Xin Zhao, Yanqiong Hu
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Abstract

Objective: To investigate the relationship between serum nesfatin-1 and insulin-like growth factor-1 (IGF-1) levels and adverse pregnancy outcomes (APOs) in patients with polycystic ovary syndrome (PCOS).

Study design: Observational study. Place and Duration of the Study: The study was performed from June 2021 to 2023 in the General Gynaecology section at the Maternity & Child Care Center of Qinhuangdao, Hebei, China.

Methodology: A total of 120 pregnant women with PCOS were divided into the control and study groups. The control group consisted of 70 pregnant women who successfully delivered healthy newborns, whereas the study group included 50 pregnant women who experienced APOs. The serum nesfatin-1 and IGF-1 levels in both groups were measured upon admission. The potential influencing factors of APOs in pregnant women with PCOS and the predictive value of serum nesfatin-1 and IGF-1 for APOs were analysed.

Results: Serum nesfatin-1 and IGF-1 levels were significantly higher in the study group than in the control group (p <0.05). Multivariate analysis revealed that testosterone ≥45 μg/L, body mass index ≥25 kg/m², waist-hip ratio ≥0.80, gestational diabetes mellitus, nesfatin-1, and IGF-1 were independent risk factors of APOs in patients with PCOS. The AUC for IGF-1 plus nesfatin-1 in predicting APOs in pregnant women with PCOS was 0.900 (95% CI: 0.845, 0.955).

Conclusion: Elevated serum nesfatin-1 and IGF-1 levels are associated with pregnancy outcomes of patients with PCOS.

Key words: Polycystic ovary syndrome, Nesfatin-1, Insulin-like growth factor-1, Adverse pregnancy outcome.

多囊卵巢综合征患者血清 Nesfatin-1 和胰岛素样生长因子-1 水平与不良妊娠结局的关系。
目的调查多囊卵巢综合征(PCOS)患者血清内司法汀-1和胰岛素样生长因子-1(IGF-1)水平与不良妊娠结局(APOs)之间的关系:观察性研究。研究地点和时间:研究时间:2021年6月至2023年6月,地点:河北省秦皇岛市妇幼保健院普通妇科:将120名多囊卵巢综合征孕妇分为对照组和研究组。方法:将 120 名多囊卵巢综合征孕妇分为对照组和研究组,对照组包括 70 名成功分娩健康新生儿的孕妇,研究组包括 50 名出现 APO 的孕妇。两组孕妇在入院时均测量了血清中 nesfatin-1 和 IGF-1 的水平。分析了多囊卵巢综合征孕妇发生 APO 的潜在影响因素以及血清奈斯法汀-1 和 IGF-1 对 APO 的预测价值:结果:研究组的血清奈斯法汀-1和IGF-1水平明显高于对照组(P血清nesfatin-1和IGF-1水平升高与多囊卵巢综合征患者的妊娠结局有关:多囊卵巢综合征 奈斯法汀-1 胰岛素样生长因子-1 不良妊娠结局
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