Comparison of the Anaemia and Transfusion Rates of Pregnant Women Treated with Intravenous versus Oral Iron in the Third Trimester.

Mustafa Cengiz Dura, Ismet Yagiz Dundar, Ozgur Aslan, Sukru Yildiz, Gulden Uzer Ekin, Murat Ekin
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Abstract

Objective: To evaluate and compare the blood transfusion requirements during delivery in third-trimester pregnant women with iron deficiency anaemia (IDA) who were treated with intravenous (IV) ferric carboxymaltose (FCM) versus those treated with oral iron supplementation.

Study design: Comparative study. Place and Duration of the Study: Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkiye, from January 2017 to December 2022.

Methodology: Pregnant women with haemoglobin (Hb) levels <10 g/dL in their third trimester were included. One group (n = 50) received IV FCM, while the other group (n = 96) received oral iron therapy. Key outcome measures included Hb levels at delivery and the need for a postpartum blood transfusion. Inclusion criteria were third-trimester pregnancy with IDA, and exclusion criteria included haematological or chronic systemic diseases and high-risk pregnancies.

Results: The mean initial Hb levels in the third trimester of pregnancy in the FCM group and oral iron group were 8.31 ± 0.96 g/dL and 9.29 ± 1.20 g/dL, respectively (p <0.001). The mean Hb levels in the delivery room were 11.09 ± 1.38 and 9.44 ± 1.16 g/dL, respectively (p <0.001). The rates of postpartum erythrocyte transfusion requirement were 6% (n = 3) and 18.75% (n = 18), respectively (p = 0.037).

Conclusion: IV FCM administration to pregnant patients with IDA during the third trimester was found to be more effective than oral iron treatment in reducing blood transfusion rates.

Key words: Anaemia, Ferric carboxymaltose, Pregnancy, Iron deficiency, Intravenous iron.

怀孕三个月时使用静脉注射铁剂和口服铁剂治疗孕妇贫血和输血率的比较。
目的评估并比较患有缺铁性贫血(IDA)的第三孕期孕妇在分娩时接受静脉注射羧甲基铁(FCM)治疗与口服铁补充剂治疗的输血需求:比较研究。研究地点和时间土耳其伊斯坦布尔 Bakirkoy Dr. Sadi Konuk 培训与研究医院,2017 年 1 月至 2022 年 12 月:孕妇血红蛋白(Hb)水平结果:在降低输血率方面,对妊娠三个月内患有 IDA 的孕妇进行静脉注射羧酸铁比口服铁剂治疗更有效:贫血;羧甲基铁;妊娠;缺铁;静脉注射铁剂。
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