Recent advances in phototherapeutic nanosystems for oral cancer

IF 6.1 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Journal of Materials Chemistry B Pub Date : 2024-10-15 DOI:10.1039/D4TB01919A

Qingqing Pan, Haofu Tang, Li Xie, Huang Zhu, Di Wu, Rong Liu, Bin He and Yuji Pu

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Abstract

Oral cancer is a significant global health challenge, with conventional treatments often resulting in substantial side effects and limited effectiveness. Phototherapy, encompassing photodynamic and photothermal therapy, presents a promising alternative by selectively targeting and destroying cancer cells with minimal systemic toxicity. However, issues such as insufficient light penetration and limited tumor specificity have restricted their clinical use. Recent advancements in nanosystems have addressed these challenges by enhancing the solubility, stability, and tumor-targeting capabilities of phototherapy agents. This review delves into the latest advancements in phototherapeutic nanosystems for oral cancer, focusing on the design of innovative nanoformulations and targeted delivery strategies. Additionally, it summarizes recent approaches to enhance the efficacy of photodynamic therapy for oral cancer and examines phototherapy-based combination treatments. These advancements hold the promise of significantly improving treatment outcomes while minimizing side effects in oral cancer therapy.

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口腔癌光疗纳米系统的最新进展。

口腔癌是全球健康面临的重大挑战，传统治疗方法往往副作用大、疗效有限。光疗（包括光动力疗法和光热疗法）可选择性地靶向破坏癌细胞，并将全身毒性降至最低，是一种很有前景的替代疗法。然而，光穿透力不足和肿瘤特异性有限等问题限制了它们在临床上的应用。纳米系统的最新进展通过提高光疗药物的溶解度、稳定性和肿瘤靶向能力，解决了这些难题。本综述深入探讨了口腔癌光疗纳米系统的最新进展，重点关注创新纳米制剂的设计和靶向给药策略。此外，它还总结了提高口腔癌光动力疗法疗效的最新方法，并研究了基于光疗法的综合疗法。这些进展有望显著提高治疗效果，同时将口腔癌治疗的副作用降至最低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.30%

发文量

866

期刊介绍： Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive： Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices