Recent advances in phototherapeutic nanosystems for oral cancer.

Journal of materials chemistry. B Pub Date : 2024-10-18 DOI:10.1039/d4tb01919a

Qingqing Pan, Haofu Tang, Li Xie, Huang Zhu, Di Wu, Rong Liu, Bin He, Yuji Pu

{"title":"Recent advances in phototherapeutic nanosystems for oral cancer.","authors":"Qingqing Pan, Haofu Tang, Li Xie, Huang Zhu, Di Wu, Rong Liu, Bin He, Yuji Pu","doi":"10.1039/d4tb01919a","DOIUrl":null,"url":null,"abstract":"<p><p>Oral cancer is a significant global health challenge, with conventional treatments often resulting in substantial side effects and limited effectiveness. Phototherapy, encompassing photodynamic and photothermal therapy, presents a promising alternative by selectively targeting and destroying cancer cells with minimal systemic toxicity. However, issues such as insufficient light penetration and limited tumor specificity have restricted their clinical use. Recent advancements in nanosystems have addressed these challenges by enhancing the solubility, stability, and tumor-targeting capabilities of phototherapy agents. This review delves into the latest advancements in phototherapeutic nanosystems for oral cancer, focusing on the design of innovative nanoformulations and targeted delivery strategies. Additionally, it summarizes recent approaches to enhance the efficacy of photodynamic therapy for oral cancer and examines phototherapy-based combination treatments. These advancements hold the promise of significantly improving treatment outcomes while minimizing side effects in oral cancer therapy.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of materials chemistry. B","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/d4tb01919a","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Oral cancer is a significant global health challenge, with conventional treatments often resulting in substantial side effects and limited effectiveness. Phototherapy, encompassing photodynamic and photothermal therapy, presents a promising alternative by selectively targeting and destroying cancer cells with minimal systemic toxicity. However, issues such as insufficient light penetration and limited tumor specificity have restricted their clinical use. Recent advancements in nanosystems have addressed these challenges by enhancing the solubility, stability, and tumor-targeting capabilities of phototherapy agents. This review delves into the latest advancements in phototherapeutic nanosystems for oral cancer, focusing on the design of innovative nanoformulations and targeted delivery strategies. Additionally, it summarizes recent approaches to enhance the efficacy of photodynamic therapy for oral cancer and examines phototherapy-based combination treatments. These advancements hold the promise of significantly improving treatment outcomes while minimizing side effects in oral cancer therapy.

查看原文本刊更多论文

口腔癌光疗纳米系统的最新进展。

口腔癌是全球健康面临的重大挑战，传统治疗方法往往副作用大、疗效有限。光疗（包括光动力疗法和光热疗法）可选择性地靶向破坏癌细胞，并将全身毒性降至最低，是一种很有前景的替代疗法。然而，光穿透力不足和肿瘤特异性有限等问题限制了它们在临床上的应用。纳米系统的最新进展通过提高光疗药物的溶解度、稳定性和肿瘤靶向能力，解决了这些难题。本综述深入探讨了口腔癌光疗纳米系统的最新进展，重点关注创新纳米制剂的设计和靶向给药策略。此外，它还总结了提高口腔癌光动力疗法疗效的最新方法，并研究了基于光疗法的综合疗法。这些进展有望显著提高治疗效果，同时将口腔癌治疗的副作用降至最低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of materials chemistry. B 化学科学, 工程与材料, 生命科学, 分析化学, 高分子组装与超分子结构, 高分子科学, 免疫生物学, 免疫学, 生化分析及生物传感, 组织工程学, 生物力学与组织工程学, 资源循环科学, 冶金与矿业, 生物医用高分子材料, 有机高分子材料, 金属材料的制备科学与跨学科应用基础, 金属材料, 样品前处理方法与技术, 有机分子功能材料化学, 有机化学

CiteScore

12.00

自引率

0.00%

发文量

审稿时长

1 months