{"title":"Bioinspired peptide/polyamino acid assemblies as quorum sensing inhibitors for the treatment of bacterial infections.","authors":"Yanan Jiang, Fanying Meng, Zhenghong Ge, Yuxiao Zhou, Zhen Fan, Jianzhong Du","doi":"10.1039/d4tb01685h","DOIUrl":null,"url":null,"abstract":"<p><p>Insufficient development of new antibiotics and the rise in antimicrobial resistance are putting the world at risk of losing curative medicines against bacterial infection. Quorum sensing is a type of cellular signaling for cell-to-cell communication that plays critical roles in biofilm formation and antimicrobial resistance, and is expected to be a new type of effective target for drug resistant bacteria. In this review we highlight recent advances in bioinspired peptide/polyamino acid assemblies as quorum sensing inhibitors across various microbial communities. In addition, existing obstacles and future development directions of peptide/polyamino acid assemblies as quorum sensing inhibitors were proposed for broader clinical applications and translations. Overall, quorum sensing peptide/polyamino acid assemblies could be vital tools against bacterial infection and antimicrobial resistance.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of materials chemistry. B","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/d4tb01685h","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Insufficient development of new antibiotics and the rise in antimicrobial resistance are putting the world at risk of losing curative medicines against bacterial infection. Quorum sensing is a type of cellular signaling for cell-to-cell communication that plays critical roles in biofilm formation and antimicrobial resistance, and is expected to be a new type of effective target for drug resistant bacteria. In this review we highlight recent advances in bioinspired peptide/polyamino acid assemblies as quorum sensing inhibitors across various microbial communities. In addition, existing obstacles and future development directions of peptide/polyamino acid assemblies as quorum sensing inhibitors were proposed for broader clinical applications and translations. Overall, quorum sensing peptide/polyamino acid assemblies could be vital tools against bacterial infection and antimicrobial resistance.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
