Can physical parameters from radiation simulation scan with deep inspiratory breath hold predict magnitude of heart dose reduction?

Venkatesan Kannan, Sudesh Deshpande, Vivek Anand, Suresh Naidu, Kamalnayan Chauhan, Nazneen Chougle, Ritika Harjani Hinduja
{"title":"Can physical parameters from radiation simulation scan with deep inspiratory breath hold predict magnitude of heart dose reduction?","authors":"Venkatesan Kannan, Sudesh Deshpande, Vivek Anand, Suresh Naidu, Kamalnayan Chauhan, Nazneen Chougle, Ritika Harjani Hinduja","doi":"10.4103/jcrt.jcrt_2668_22","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Deep inspiratory breath hold is one of the techniques for reducing the heart doses for left breast cancers. This study was conducted to confirm use of physical parameters from DIBH simulation CT scan like DIBH amplitude alongside several novel parameters to predict the heart dose reduction.</p><p><strong>Materials and methods: </strong>Segmentation and planning of radiation to the left breast on the free breathing (FB) and DIBH simulation scan was performed for 50 left-sided breast cancer patients treated with DIBH technique. Physical parameters, namely DIBH amplitude, anterior sternal displacement, diaphragmatic excursion, ratio of lung volume (cc) in DIBH scan to lung volume in FB scan (cc), and delta heart volume in field (DHVIF), were extracted and were compared with magnitude of heart dose reduction (mean heart dose, V30Gy, and D5%).</p><p><strong>Results: </strong>Forty-eight (96%) patients achieved reduction in the mean heart dose with DIBH technique, while all patients had reduction in V30Gy. The median reduction was 41%, 89.7%, and 63% in the mean dose, V30Gy, and D5%, respectively. While DIBH did not correlate with heart dose reduction, ratio of lung volumes and DHVIF showed a strong positive correlation with heart dose reduction (P < 0.05). Sternal displacement correlated weakly with heart dose reduction but strongly with DHVIF, demonstrating to be an indirect predictor.</p><p><strong>Conclusions: </strong>Physical parameters like anterior sternal displacement, ratio of lung volumes of DIBH to FB, and possibly diaphragmatic movement can predict the dose reduction before the dose calculations by the physicist. These parameters can be used to construct a model to predict heart dose reduction.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"20 5","pages":"1539-1544"},"PeriodicalIF":0.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of cancer research and therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jcrt.jcrt_2668_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/22 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: Deep inspiratory breath hold is one of the techniques for reducing the heart doses for left breast cancers. This study was conducted to confirm use of physical parameters from DIBH simulation CT scan like DIBH amplitude alongside several novel parameters to predict the heart dose reduction.

Materials and methods: Segmentation and planning of radiation to the left breast on the free breathing (FB) and DIBH simulation scan was performed for 50 left-sided breast cancer patients treated with DIBH technique. Physical parameters, namely DIBH amplitude, anterior sternal displacement, diaphragmatic excursion, ratio of lung volume (cc) in DIBH scan to lung volume in FB scan (cc), and delta heart volume in field (DHVIF), were extracted and were compared with magnitude of heart dose reduction (mean heart dose, V30Gy, and D5%).

Results: Forty-eight (96%) patients achieved reduction in the mean heart dose with DIBH technique, while all patients had reduction in V30Gy. The median reduction was 41%, 89.7%, and 63% in the mean dose, V30Gy, and D5%, respectively. While DIBH did not correlate with heart dose reduction, ratio of lung volumes and DHVIF showed a strong positive correlation with heart dose reduction (P < 0.05). Sternal displacement correlated weakly with heart dose reduction but strongly with DHVIF, demonstrating to be an indirect predictor.

Conclusions: Physical parameters like anterior sternal displacement, ratio of lung volumes of DIBH to FB, and possibly diaphragmatic movement can predict the dose reduction before the dose calculations by the physicist. These parameters can be used to construct a model to predict heart dose reduction.

深吸气屏气的辐射模拟扫描物理参数能否预测心脏剂量减少的幅度?
简介深吸气屏气是减少左乳腺癌心脏剂量的技术之一。这项研究旨在确认深吸气憋气模拟 CT 扫描的物理参数(如深吸气憋气振幅)与几个新参数的结合使用,以预测心脏剂量的减少:对 50 名采用 DIBH 技术治疗的左侧乳腺癌患者进行了自由呼吸(FB)和 DIBH 模拟扫描,并对左侧乳房的放射线进行了分割和规划。提取了物理参数,即 DIBH 振幅、胸骨前位移、膈肌偏移、DIBH 扫描肺容积(cc)与 FB 扫描肺容积(cc)之比和心场内三角洲容积(DHVIF),并与心脏剂量减少幅度(平均心脏剂量、V30Gy 和 D5%)进行了比较:结果:48 名患者(96%)通过 DIBH 技术减少了平均心脏剂量,所有患者的 V30Gy 均有减少。平均剂量、V30Gy 和 D5% 的中位降低率分别为 41%、89.7% 和 63%。虽然 DIBH 与心脏剂量减少无关,但肺容积比和 DHVIF 与心脏剂量减少呈强正相关(P < 0.05)。胸骨移位与心脏剂量减少的相关性较弱,但与 DHVIF 的相关性较强,这表明胸骨移位是一个间接的预测指标:结论:物理参数,如胸骨前位移、DIBH与FB的肺容积之比,以及可能的膈肌运动,可以在物理学家计算剂量之前预测剂量减少。这些参数可用于构建预测心脏剂量减少的模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信