Photobiomodulation on Full-Thickness Skin Graft Survival in Rats

IF 2 3区物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS

Journal of Biophotonics Pub Date : 2024-10-17 DOI:10.1002/jbio.202400285

Lara Maria Bataglia Espósito, Maria Carolina Derencio Oliveira, Luis Henrique Oliveira de Moraes, Camila Pereira Sabadini, Krissia Franco de Godoy, Rafael Afonso Derencio Oliveira, Ana Cláudia Garcia de Oliveira Duarte, Fernanda de Freitas Anibal, Gerson Jhonatan Rodrigues, Patricia Brassolatti, Richard Eloin Liebano

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Abstract

Objective

To evaluate the photobiomodulation effects on the receptor area for full-thickness skin graft integration.

Methods

Thirty-Six Wistar rats were divided: red laser (660 nm), infrared laser (808 nm), and control. A skin segment with 5 × 3 cm was removed. In the control, the skin was reallocated after a 180° rotation. For the 660 nm and 808 nm, the receptor area was first irradiated, and then the skin was reallocated the same as the control. Euthanasia occurred on the third and seventh days after the procedure, and macroscopical of necrosis and histological analysis were realized.

Results

The 660 nm reached the lowest necrosis percentage on Day 7. In the 808 nm, necrosis increased between the two periods. Similar morphological findings were observed for the control and 660 nm; however, the 808 nm showed significant alterations in fibrosis and inflammatory infiltrate.

Conclusion

The infrared wavelength showed inferior performance on skin graft integration compared to the control and the red wavelength.

Abstract Image

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光生物调节对大鼠全厚皮肤移植存活率的影响

目的评估光生物调节对全厚植皮整合受体区域的影响：方法：将 36 只 Wistar 大鼠分为红色激光（660 nm）、红外激光（808 nm）和对照组。切除一块 5 × 3 厘米的皮肤。在对照组中，皮肤旋转 180° 后重新分配。对于 660 纳米和 808 纳米激光，首先照射受体区域，然后与对照组一样重新分配皮肤。手术后第三天和第七天实施安乐死，并对坏死进行宏观观察和组织学分析：结果：第 7 天，660 纳米的坏死率最低。在 808 nm 中，坏死率在两个时期之间有所增加。对照组和 660 纳米波长下观察到的形态学结果相似；但 808 纳米波长下纤维化和炎症浸润有显著变化：结论：与对照组和红色波长相比，红外线波长在植皮整合方面表现较差。

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来源期刊

Journal of Biophotonics 生物-生化研究方法

CiteScore

5.70

自引率

7.10%

发文量

248

审稿时长

1 months

期刊介绍： The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.