Effect of Photobiomodulation on an Experimental Model of Lower Limb Ischemia

IF 2 3区物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS

Journal of Biophotonics Pub Date : 2024-10-14 DOI:10.1002/jbio.202400305

Silvana Torres Perez, Lucas Andreo, José Antonio Silva Junior, Sandra Kalil Bussadori, Anna Carolina Ratto Tempestini Horliana, Raquel Agnelli Mesquita-Ferrari, Kristianne Porta Santos Fernandes

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Abstract

Photobiomodulation (PBM) has been shown to be promising for the promotion of angiogenesis. The present study investigated the effects of PBM on vascularization in an animal model of peripheral artery disease. Wistar rats were divided into three groups. The control group received no procedures. The ischemia group was submitted to ligation of the femoral artery of the hindleg. The ischemia + PBM group was submitted to ligation of the femoral artery followed by PBM (660 and 808 nm, 100 mW, 4 J) over the site. Animals with ischemia treated with PBM exhibited comparable results to the control group with regards to the diameter of the α-SMA+ vessels, cross-sectional area of muscle fibers, percentage of collagen and serum concentration of IL-17A, as well as similarities in terms of vertical mobility, temperature of the hindleg, number of acts of grooming, and percentage of movement, indicating a condition like that of limbs unaffected by ischemia.

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光生物调节对下肢缺血实验模型的影响

光生物调节（PBM）已被证明在促进血管生成方面大有可为。本研究调查了 PBM 对外周动脉疾病动物模型血管生成的影响。Wistar 大鼠被分为三组。对照组不接受任何治疗。缺血组结扎后腿股动脉。缺血 + PBM 组结扎股动脉，然后在该部位进行 PBM（660 和 808 纳米，100 毫瓦，4 焦耳）治疗。接受 PBM 治疗的缺血动物在 α-SMA+ 血管直径、肌纤维横截面积、胶原蛋白百分比和 IL-17A 血清浓度方面的结果与对照组相当，在垂直移动能力、后腿温度、梳理次数和移动百分比方面也与对照组相似，表明其状况与未受缺血影响的肢体相同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biophotonics 生物-生化研究方法

CiteScore

5.70

自引率

7.10%

发文量

248

审稿时长

1 months

期刊介绍： The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.