Understanding the Relationship between the Ketogenic Diet and the Heart: A Novel Therapeutic Potential for Cardiovascular Health.

Cardiovascular & hematological agents in medicinal chemistry Pub Date : 2024-01-01 DOI:10.2174/0118715257267341231031120105

Priyanshi Shah, Aanchal Sawhney, Fnu Anamika, Sai Gautham Kanagala, Kinna Parikh, Vaidehi Mendpara, Nikita Garg, Rohit Jain

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Abstract

Obesity and cardiovascular diseases are major health problems worldwide, and weight loss is used as a treatment strategy to enhance various aspects. While there are many weight loss methods, one of the most effective is through a dietary approach. The ketogenic diet (KD), which is characterized by low carbohydrates and high levels of fat and/or protein, is used in obese patients as it is a promising treatment option for weight loss as well as for controlling the risk factors for cardiovascular diseases, as seen in its effects on cardio-metabolic outcomes, particularly in obesity, heart failure, and hypertension. In this review, we summarize the clinical evidence of the efficacy and safety of the KD in controlling risk factors for cardiovascular diseases and discuss the possible mechanisms of action based on recent evidence in understanding the influence of the KD at the cellular and molecular levels.

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了解生酮饮食与心脏的关系：心血管健康的新治疗潜力。

肥胖症和心血管疾病是世界范围内的主要健康问题，减肥作为一种治疗策略被用来改善各方面的状况。虽然减肥方法有很多，但最有效的方法之一是饮食疗法。生酮饮食（KD）的特点是低碳水化合物、高脂肪和/或蛋白质，被用于肥胖患者，因为它对心血管代谢结果，尤其是肥胖、心力衰竭和高血压的影响可见一斑，是一种很有前景的减肥和控制心血管疾病风险因素的治疗方法。在这篇综述中，我们总结了 KD 在控制心血管疾病风险因素方面的有效性和安全性的临床证据，并根据最近了解 KD 在细胞和分子水平影响的证据，讨论了其可能的作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cardiovascular & hematological agents in medicinal chemistry

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