Sarcoidosis: A Review of the Guidelines and What's To Come.

Abstract

Sarcoidosis is a disease hallmarked by granulomatous inflammation of nearly all organ systems. Though it has been widely recognized for over 100 years, much remains unknown about the etiology and pathophysiology of the disease. Due in part to this is ambiguity, diagnosis and treatment, algorithms have been difficult to create and even harder to develop a strong evidence base for. In this article, we attempt to consolidate the guidelines, recommendations, and algorithms provided by multiple societies across the US and abroad. We have assembled these into a concise quick-reference format article for those looking for a cohesive approach to the diagnosis and management of sarcoidosis, including when it doesn't respond to initial therapy. We also delve into a new and promising treatment that is in the investigation pipeline, but not yet ready for implementation.