Multifunctional nano co-delivery system for efficiently eliminating neuroblastoma by overcoming cancer heterogeneity.

Shungen Huang, Xian Yang, Yajuan Gao, Haoying Huang, Tuanwei Li, Meng Li, Feng Wu, Hongcao Yang, Chunyan Li
{"title":"Multifunctional nano co-delivery system for efficiently eliminating neuroblastoma by overcoming cancer heterogeneity.","authors":"Shungen Huang, Xian Yang, Yajuan Gao, Haoying Huang, Tuanwei Li, Meng Li, Feng Wu, Hongcao Yang, Chunyan Li","doi":"10.1088/1748-605X/ad8826","DOIUrl":null,"url":null,"abstract":"<p><p>The high heterogeneity of neuroblastoma (NB) is currently the main challenge in clinical treatment, impeding the complete eradication of the tumor through monotherapy alone. In this study, we propose a combination strategy using a targeted nano co-delivery system (ADRF@Ag<sub>2</sub>Se) comprising phototheranostic agents, differentiation inducers and chemotherapy drugs for sequential therapy of NB. Upon intravenous injection, ADRF@Ag<sub>2</sub>Se demonstrates effective tumor targeting by the specific binding of AF7P to MMP14, which is overexpressed on the surface of NB cells. Subsequent implementation of local photothermal therapy (PTT) leverages the robust photothermal conversion capabilities of the amphiphilic photothermal reagent PF. This is followed by the temperature-triggered release of differentiation-inducing agent 13-<i>cis</i>-retinoic acid and chemo-drug doxorubicin to synergistically eliminate the residual lesions. This nanotherapeutic strategy facilitates<i>in vivo</i>targeted delivery and PTT under the supervision of NIR-II fluorescence, and it also enhances the chemotherapeutic response through differentiation induction of poorly differentiated cancer cells. In the NB tumor model, this co-delivery strategy effectively inhibited tumor growth and significantly prolonged the survival of the mice.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical materials (Bristol, England)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1088/1748-605X/ad8826","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

The high heterogeneity of neuroblastoma (NB) is currently the main challenge in clinical treatment, impeding the complete eradication of the tumor through monotherapy alone. In this study, we propose a combination strategy using a targeted nano co-delivery system (ADRF@Ag2Se) comprising phototheranostic agents, differentiation inducers and chemotherapy drugs for sequential therapy of NB. Upon intravenous injection, ADRF@Ag2Se demonstrates effective tumor targeting by the specific binding of AF7P to MMP14, which is overexpressed on the surface of NB cells. Subsequent implementation of local photothermal therapy (PTT) leverages the robust photothermal conversion capabilities of the amphiphilic photothermal reagent PF. This is followed by the temperature-triggered release of differentiation-inducing agent 13-cis-retinoic acid and chemo-drug doxorubicin to synergistically eliminate the residual lesions. This nanotherapeutic strategy facilitatesin vivotargeted delivery and PTT under the supervision of NIR-II fluorescence, and it also enhances the chemotherapeutic response through differentiation induction of poorly differentiated cancer cells. In the NB tumor model, this co-delivery strategy effectively inhibited tumor growth and significantly prolonged the survival of the mice.

通过克服癌症异质性有效消除神经母细胞瘤的多功能纳米联合给药系统。
神经母细胞瘤(NB)的高度异质性是目前临床治疗的主要挑战,阻碍了单药治疗对肿瘤的彻底根治。在这项研究中,我们提出了一种由光抑制剂、分化诱导剂和化疗药物组成的靶向纳米联合给药系统(ADRF@Ag2Se)的组合策略,用于NB的序贯治疗。经静脉注射后,ADRF@Ag2Se通过AF7P与NB细胞表面过度表达的MMP14特异性结合,显示出有效的肿瘤靶向性。随后的局部光热疗法利用了两亲性光热试剂 PF 强大的光热转换能力。随后,在温度触发下释放分化诱导剂 13-顺式维甲酸(13-cis-RA)和化疗药物多柔比星(DOX),协同消除残留病灶。这种纳米治疗策略有助于在近红外-II 荧光的监控下进行体内靶向给药和光热治疗,还能通过诱导分化不良的癌细胞分化来增强化疗反应。在 NB 肿瘤模型中,这种联合给药策略有效抑制了肿瘤的生长,并显著延长了小鼠的生存期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信