Reference values for cerebral and peripheral tissue oximetry in children: A clinical TD-NIRS study

IF 2.4 4区医学 Q1 PEDIATRICS

Acta Paediatrica Pub Date : 2024-10-19 DOI:10.1111/apa.17459

Valeria Calcaterra, Michele Lacerenza, Virginia Rossi, Sara Zanelli, Davide Contini, Caterina Amendola, Mauro Buttafava, Alessandro Torricelli, Gianvincenzo Zuccotti

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引用次数: 0

Abstract

Aim

Current non-invasive near-infrared spectroscopy (NIRS) tissue oximetry suffers from suboptimal reproducibility over probe repositioning, hindering clinical threshold establishment. Time Domain-NIRS (TD-NIRS) offers higher precision but lacks sufficient paediatric data, preventing effective clinical application. We aimed to establish reference ranges for cerebral and mid-upper arm (MUA) tissue haemodynamics in paediatric subjects using TD-NIRS and explore correlations with auxological variables.

Methods

TD-NIRS measurements were conducted acquiring data from cerebral and MUA regions with the NIRSBOX tissue oximeter. Morphological and clinically relevant information were collected to explore potential correlations with TD-NIRS derived parameters.

Results

TD-NIRS assessment was applied in 350 children (8.4 ± 5.0 years). Precision of TD-NIRS was demonstrated with standard deviations of 0.9% (StO₂) and 4.2 μM (tHb) for frontotemporal cerebral cortex, and 0.8% (StO₂) and 3.7 μM (tHb) for MUA. No user dependency was observed. The trends of values for cerebral and peripheral regions vary differently according to age and auxological parameters.

Conclusion

This study reports resting-state optical and haemodynamic values for a healthy paediatric population, providing a foundation for future investigations into clinically relevant deviations in these parameters. Furthermore, correlations with anthropometric and demographic values provide valuable insights for a deeper understanding of tissue haemodynamic evolution in childhood.

Abstract Image

查看原文本刊更多论文

儿童大脑和外周组织血氧饱和度参考值：TD-NIRS 临床研究。

目的：目前的无创近红外光谱仪（NIRS）组织血氧测量法在探头重新定位时存在重复性不佳的问题，妨碍了临床阈值的确定。时域近红外（TD-NIRS）具有更高的精确度，但缺乏足够的儿科数据，无法有效地应用于临床。我们的目的是利用 TD-NIRS 建立儿科受试者大脑和中上臂（MUA）组织血流动力学的参考范围，并探索与辅助变量的相关性：方法：使用 NIRSBOX 组织血氧仪进行 TD-NIRS 测量，获取大脑和 MUA 区域的数据。收集形态学和临床相关信息，探讨与 TD-NIRS 导出参数的潜在相关性：结果：350 名儿童（8.4 ± 5.0 岁）接受了 TD-NIRS 评估。TD-NIRS 的精确度得到了证实，额颞叶大脑皮层的标准偏差为 0.9%（StO2）和 4.2 μM（tHb），MUA 的标准偏差为 0.8%（StO2）和 3.7 μM（tHb）。没有观察到使用者依赖性。大脑和外周区域的数值趋势因年龄和辅助参数而异：本研究报告了健康儿科人群的静息状态光学和血流动力学值，为今后研究这些参数的临床相关偏差奠定了基础。此外，与人体测量值和人口统计学值的相关性为深入了解儿童组织血流动力学的演变提供了宝贵的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Paediatrica 医学-小儿科

CiteScore

6.50

自引率

5.30%

发文量

384

审稿时长

2-4 weeks

期刊介绍： Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries