Effect of Low Molecular Weight Heparin Calcium on Prevention of Lower Limb Deep Venous Thrombosis in Oral Cancer Patients With Anterolateral Thigh Flap Reconstruction.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-10-18 DOI:10.1002/hed.27947

Keyue Liu, Linsong Lu, Yuan Zhi, Moxin Zi, Xiangyu Zhang, Kun Wu, Zhaojian Gong

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Abstract

Background: This study aimed to evaluate the effect of low molecular weight heparin calcium (LMWH-Ca) on the prevention of deep venous thrombosis (DVT) in patients with anterolateral thigh (ALT) flap reconstruction.

Methods: In total, 1001 patients with oral cancer who underwent ALT flap reconstruction were recruited. Based on the postoperative use of LMWH-Ca, the patients were divided into case (n = 633) and control groups (n = 368). The incidence of postoperative DVT was compared between groups.

Results: There was no significant difference in DVT incidence between the two groups. Among patients older than 60 years, the incidence of lower limb DVT in the case group (0.813%) was significantly lower than that in the control group (8.108%, p = 0.012).

Conclusion: The postoperative use of LMWH in oral cancer patients with ALT flap transfer does not prevent the development of lower limb DVT. However, patients older than 60 years old benefited from the postoperative use of LMWH-Ca.

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低分子量肝素钙对预防口腔癌患者大腿前外侧皮瓣重建术后下肢深静脉血栓形成的影响

研究背景本研究旨在评估低分子量肝素钙（LMWH-Ca）对大腿前外侧（ALT）皮瓣重建患者深静脉血栓（DVT）的预防效果：方法：共招募了 1001 名接受 ALT 皮瓣重建术的口腔癌患者。根据术后使用 LMWH-Ca 的情况，将患者分为病例组（n = 633）和对照组（n = 368）。比较两组患者术后深静脉血栓的发生率：结果：两组患者的深静脉血栓发生率无明显差异。在 60 岁以上的患者中，病例组下肢深静脉血栓的发生率（0.813%）明显低于对照组（8.108%，P = 0.012）：结论：ALT皮瓣转移的口腔癌患者术后使用LMWH并不能预防下肢深静脉血栓的发生。结论：口腔癌患者进行 ALT 皮瓣转移术后使用 LMWH 并不能预防下肢深静脉血栓的发生，但 60 岁以上的患者可从术后使用 LMWH-Ca 中获益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.