Long-Term Mental Health Outcomes of Bronchopulmonary Dysplasia in Neonates: An 18-Year National Cohort Study

IF 3.9 2区医学 Q1 PEDIATRICS

Journal of Pediatrics Pub Date : 2024-10-18 DOI:10.1016/j.jpeds.2024.114341

Ga Won Jeon MD , Jaeho Shin MD , Ju Hee Kim MD , Eun Kyo Ha MD , Bo Eun Han BS , Ha Na Yoo MS , Soonchul Lee MD , Man Yong Han MD

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引用次数: 0

Abstract

Objective

To evaluate the association between neonatal bronchopulmonary dysplasia and the subsequent development of mental health conditions in children and adolescents.

Study design

This was a retrospective cohort study, utilizing data from individuals born in South Korea between 2002 and 2005 and followed up until 2021, using the National Health Insurance Database. The cohort included 1 893 314 participants born during that period, with 927 diagnosed with bronchopulmonary dysplasia during the neonatal period (the exposed cohort). They were matched 1:10 with 9270 unexposed individuals (the unexposed cohort) based on key demographic factors.

Results

The median age at the first mental health disorder diagnosis was 9 years (IQR, 5-15 years), with 5698 individuals (55.9%) being male. During an average follow-up of 15.2 years, the incidence rate was 481/10 000 person-years in the exposed and 138 of 10 000 person-years in the unexposed cohort. By the age of 18 years, the cumulative incidence in the exposed cohort was 54% (95% CI; 50%-57%), with an adjusted hazard ratio of 3.18 (95% CI; 2.81-3.60) compared with the unexposed cohort, and adjusted hazard ratios for early- and late-onset mental health disorders of 4.48 (95% CI; 3.84-5.22) and 1.89 (95% CI; 1.61-2.22), respectively. Sensitivity analyses confirmed these findings, and a subgroup analysis revealed a higher risk among individuals with bronchopulmonary dysplasia who required prolonged respiratory support or oxygen.

Conclusions

Half of children with bronchopulmonary dysplasia in our cohort developed mental health disorders by the age of 18 years, emphasizing the need for interventions and support for such individuals.

查看原文本刊更多论文

新生儿支气管肺发育不良的长期心理健康后果：一项为期 18 年的全国队列研究。

研究目的研究设计：这是一项回顾性队列研究，利用国民健康保险数据库中 2002 年至 2005 年间在韩国出生并随访至 2021 年的个体数据。该队列包括 1,893,314 名在此期间出生的参与者，其中 927 人在新生儿期被诊断为支气管肺发育不良（暴露队列）。根据主要人口统计学因素，他们与 9,270 名未暴露者（未暴露队列）进行了 1:10 匹配：首次诊断出精神障碍的中位年龄为 9 岁（四分位数间距为 5-15 岁），其中 5,698 人（55.9%）为男性。在平均 15.2 年的随访期间，暴露人群的发病率为 481/10,000人年，未暴露人群的发病率为 138/10,000人年。到18岁时，暴露人群的累积发病率为54%（95%置信区间[CI]；50%-57%），与未暴露人群相比，调整后的危险比为3.18（95% CI；2.81-3.60），早期和晚期精神疾病的调整后危险比分别为4.48（95% CI；3.84-5.22）和1.89（95% CI；1.61-2.22）。敏感性分析证实了这些结果，一项亚组分析显示，需要长期呼吸支持或氧气的支气管肺发育不良患者的风险更高：结论：在我们的队列中，半数患有支气管肺发育不良的儿童在18岁时出现了心理健康障碍，这强调了对这些儿童进行干预和提供支持的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pediatrics 医学-小儿科

CiteScore

6.00

自引率

2.00%

发文量

696

审稿时长

31 days

期刊介绍： The Journal of Pediatrics is an international peer-reviewed journal that advances pediatric research and serves as a practical guide for pediatricians who manage health and diagnose and treat disorders in infants, children, and adolescents. The Journal publishes original work based on standards of excellence and expert review. The Journal seeks to publish high quality original articles that are immediately applicable to practice (basic science, translational research, evidence-based medicine), brief clinical and laboratory case reports, medical progress, expert commentary, grand rounds, insightful editorials, “classic” physical examinations, and novel insights into clinical and academic pediatric medicine related to every aspect of child health. Published monthly since 1932, The Journal of Pediatrics continues to promote the latest developments in pediatric medicine, child health, policy, and advocacy. Topics covered in The Journal of Pediatrics include, but are not limited to: General Pediatrics Pediatric Subspecialties Adolescent Medicine Allergy and Immunology Cardiology Critical Care Medicine Developmental-Behavioral Medicine Endocrinology Gastroenterology Hematology-Oncology Infectious Diseases Neonatal-Perinatal Medicine Nephrology Neurology Emergency Medicine Pulmonology Rheumatology Genetics Ethics Health Service Research Pediatric Hospitalist Medicine.