Acupuncture's Emergence as A Promising Non-Pharmacological Therapy for Appetite Management in Cancer Chemotherapy.

IF 2 4区医学 Q3 NUTRITION & DIETETICS

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-10-13 DOI:10.1080/01635581.2024.2413717

Xu Zhang, Wenjing Yang, Junliang Shang, Lin Shi, Lu Yang, Chi Zhang, Yuyi Chen, Zishen Liu, Bo Li, Xinghan Zhang, Li Tong, Guowang Yang

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引用次数: 0

Abstract

Objective: The primary objective of this investigation was to assess the impact of acupuncture intervention and explore the intricacies of acupoint selection as a therapeutic strategy for chemotherapy-induced Anorexia (CIA).

Method: Eight electronic databases were searched to identify relevant studies on the use of acupuncture for the treatment of CIA to conduct a comprehensive meta-analysis. Following this, the Apriori algorithm, correlation analysis, and cluster analysis were performed to identify correlations between the selection of acupoints.

Results: Acupuncture significantly reduced the incidence of anorexia (RR = 0.76, 95%CI: 0.65, 0.90; I²=63%; p = 0.001; n = 503) and anorexia score (SMD=-0.33, 95%CI: -0.53, -0.14; I²=22%; p = 0.0008; n = 419), as well as preserved body mass (MD = 2.70, 95%CI: 1.08, 4.32; I²=0%; p = 0.001; n = 187) and enhanced physical strength (MD = 4.23, 95%CI: 1.90, 6.55; I²=58%; p = 0.0004; n = 377). Moreover, subgroup analysis highlighted its efficacy in managing anorexia associated with non-gastrointestinal tumors and mitigating the severity of cisplatin-induced anorexia. Meanwhile, Zusanli (ST36), Neiguan (PC6), Tianshu (ST25), Zhongwan (RN12), and Qihai (RN6) were identified as crucial acupoints in CIA management.

Conclusion: Acupuncture holds promise as a potential non-pharmacological approach for managing anorexia during cancer chemotherapy. To provide robust evidence of its effectiveness, well-designed Randomized Controlled Trials (RCTs) with larger participant cohorts, and consistent core outcome measures are essential.

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针灸作为非药物疗法在癌症化疗中调理食欲方面的应用前景广阔。

研究目的本研究的主要目的是评估针灸干预的影响，并探索穴位选择作为化疗诱发性厌食症（CIA）治疗策略的复杂性：方法：检索了八个电子数据库，以确定使用针灸治疗 CIA 的相关研究，并进行综合荟萃分析。随后，采用 Apriori 算法、相关性分析和聚类分析来确定穴位选择之间的相关性：针灸明显降低了厌食的发生率（RR=0.76，95%CI：0.65，0.90；I2=63%；P=0.001；n=503）和厌食评分（SMD=-0.33，95%CI：-0.53，-0.14；I2=22%；P=0.0008; n = 419），以及保持体重（MD = 2.70, 95%CI: 1.08, 4.32; I2=0%; p = 0.001; n = 187）和增强体力（MD = 4.23, 95%CI: 1.90, 6.55; I2=58%; p = 0.0004; n = 377）。此外，亚组分析还强调了该药物在控制非胃肠道肿瘤相关厌食症和减轻顺铂诱导的厌食症严重程度方面的疗效。同时，足三里（ST36）、内关（PC6）、天枢（ST25）、中脘（RN12）和气海（RN6）被确定为治疗 CIA 的关键穴位：结论：针灸作为一种潜在的非药物疗法，在治疗癌症化疗期间的厌食症方面大有可为。要提供其有效性的有力证据，必须进行精心设计的随机对照试验（RCTs），以更大的参与者群和一致的核心结果测量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition and Cancer-An International Journal 医学-营养学

CiteScore

5.80

自引率

3.40%

发文量

172

审稿时长

3 months

期刊介绍： This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.