GUNN DOTS IN CHILDREN AGED 11-12 YEARS FROM THE GENERAL COMMUNITY SAMPLE COPENHAGEN CHILD COHORT 2000 STUDY.

IF 2.3 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-11-01 DOI:10.1097/IAE.0000000000004187

Lars Christian Boberg-Ans, Inger Christine Munch, Else Marie Olsen, Anne Mette Skovgaard, Michael Larsen

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Abstract

Purpose: To study characteristics and associations of Gunn dots in a cohort of healthy children aged 11 to 12 years.

Methods: As part of the Copenhagen Child Cohort 2000 Study, red-free fundus photographs were taken on 761 healthy children aged 11 to 12 years. The photographs were centered on the optic disk. Gunn dots were annotated and counted within a disk-centered circular grid of 6 mm diameter. Data were analyzed in relation to age, sex, axial length, and retinal nerve fiber layer thickness.

Results: Gunn dots were found in 716 of the 761 participants (94%). The majority of dots were located both inferior and superior to the optic disk, situated within a distance of 3 mm from its center. The median number of Gunn dots was 64 (range 0-574) in right eyes and 68 (range 0-532) in left eyes. Having more than the median number of Gunn dots in the right eye was associated with older age (odds ratio 2.12, 95% CI 1.56 to 2.89, P < 0.0001, adjusted for sex, axial length, and retinal nerve fiber layer thickness) and was less common among the children with a thinner retinal nerve fiber layer (odds ratio 0.40, 95% CI 0.26-0.60, P < 0.0001 comparing bottom and top quartiles).

Conclusion: Gunn dots were visible in the majority of healthy children aged 11 to 12 years, and large numbers of dots were associated with a thicker nerve fiber layer and with older age, within the limited age range of 1 year. The clinical significance of Gunn dots is unknown. Their location at the vitreoretinal interface makes them a parameter of interest in the study of aging, epiretinal fibrosis, macular pucker and retinal detachment.

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哥本哈根儿童队列 2000 研究一般社区样本中 11-12 岁儿童的 gunn 点。

目的：在一组 11 至 12 岁的健康儿童中研究 Gunn 点的特征和相关性：作为哥本哈根儿童队列 2000 研究的一部分，我们为 761 名 11 至 12 岁的健康儿童拍摄了无红眼底照片。照片以视盘为中心。在以视盘为中心、直径为 6 毫米的圆形网格内对 Gunn 点进行标注和计数。数据分析与年龄、性别、轴向长度和视网膜神经纤维层厚度有关：761 名参与者中有 716 人（94%）发现了 Gunn 点。大多数小点位于视盘的下部和上部，距离视盘中心不超过 3 毫米。右眼冈恩点的中位数为 64 个（范围 0-574），左眼为 68 个（范围 0-532）。右眼Gunn点数量超过中位数与年龄较大有关（几率比为2.12，95% CI为1.56至2.89，P<0.0001，已对性别、眼轴长度和视网膜神经纤维层厚度进行调整），在视网膜神经纤维层较薄的儿童中较少见（几率比为0.40，95% CI为0.26至0.60，比较下四分位数和上四分位数，P<0.0001）：大多数 11 至 12 岁的健康儿童都能看到 Gunn 点，在 1 岁的有限年龄范围内，大量的 Gunn 点与较厚的神经纤维层和较大的年龄有关。贡氏点的临床意义尚不清楚。它们位于玻璃体视网膜界面，是研究老化、视网膜外纤维化、黄斑皱褶和视网膜脱离的一个重要参数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.