Inhibiting IL11: a novel approach to turning back the clock.

IF 5.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Osama Ahmad, Muhammad Haris
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引用次数: 0

Abstract

The World Health Organization recognizes frailty and multimorbidity as major global health issues and underscores the need for effective interventions. Recent advances have identified interleukin-11 (IL-11), a pro-inflammatory cytokine, as a key player in modulating aging pathways (such as ERK, AMPK, mTOR and JAK-STAT3). Studies have shown that IL-11 inhibition can lead to improved health span and lifespan in animal models, with potential applications in humans. By targeting IL-11, researchers aim to mitigate age-related diseases, such as cancer, fibrosis, and multimorbidity, which pose significant healthcare challenges worldwide. IL-11 inhibition offers a promising strategy, with preclinical trials demonstrating its ability to regenerate renal cells, reduce hepatocyte death, and mitigate liver fibrosis. Further research is necessary to fully elucidate the mechanisms of IL-11 inhibition and its therapeutic potential. If successful, this approach could lead to the development of novel pharmacological interventions, promoting healthier aging and increasing human lifespan.

抑制 IL11:让时光倒流的新方法
世界卫生组织认为虚弱和多病是主要的全球健康问题,并强调需要采取有效的干预措施。最近的研究发现,白细胞介素-11(IL-11)是一种促炎细胞因子,是调节衰老途径(如 ERK、AMPK、mTOR 和 JAK-STAT3)的关键因素。研究表明,抑制 IL-11 可以改善动物模型的健康寿命和寿命,并有可能应用于人类。通过靶向 IL-11,研究人员旨在缓解与年龄有关的疾病,如癌症、纤维化和多病,这些疾病给全球医疗保健带来了巨大挑战。IL-11抑制剂提供了一种前景广阔的策略,临床前试验证明它能够再生肾细胞、减少肝细胞死亡和减轻肝纤维化。要全面阐明 IL-11 抑制的机制及其治疗潜力,还需要进一步的研究。如果研究成功,这种方法将有助于开发新型药物干预措施,促进健康老龄化并延长人类寿命。
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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
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