Walking training decreases cardiovascular load after walking to maximal intermittent claudication in patients with peripheral artery disease

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology Pub Date : 2024-10-19 DOI:10.1016/j.cpcardiol.2024.102887

Aluisio Andrade-Lima , Natan D. Silva Junior , Marcel R. Chehuen , Roberto S. Miyasato , Patricia C. Brum , Edilamar M. Oliveira , Anthony S. Leicht , Nelson Wolosker , Claudia L.M. Forjaz

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引用次数: 0

Abstract

Purpose

This study investigated whether: 1) walking training (WT) changes cardiovascular load after walking until maximal intermittent claudication (IC) in patients with peripheral artery disease (PAD); and 2) acute and chronic cardiovascular responses to walking were related to each other.

Methods

A randomized, controlled, parallel-group design was employed. Thirty-two men with PAD and IC were randomly assigned to one of two groups: WT (n=16) or control (CO, n=16) twice a week for 12 weeks. The WT group completed 15, 2-min bouts of walking at moderate intensity interspersed with 2-min upright resting intervals per session. The CO group completed 30 minutes of stretching per session. At Baseline and after 12 weeks, both groups underwent a progressive walking session to maximal IC (3.2 km/h, 2% increase in grade every 2 min). Systolic blood pressure (BP), diastolic BP, heart rate (HR), and rate pressure product (RPP) were measured pre- and post-walking. Data were analyzed by three-way mixed ANOVAs. Pearson correlations were used to explore the association between the acute and chronic responses.

Results

WT significantly reduced pre- and post-walking systolic BP (p<0.001), diastolic BP (p<0.001), and RPP (p<0.001). No significant correlations were found between the acute and chronic changes observed for all variables (all p>0.05).

Conclusion

In patients with PAD, WT decreased cardiovascular load assessed before and after walking to maximal IC. Furthermore, the acute and chronic cardiovascular responses to walking were not associated. Thus, WT may reduce the risk of immediate post-walking cardiac events in susceptible patients.

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步行训练可降低外周动脉疾病患者步行至最大间歇性跛行后的心血管负荷。

目的：本研究探讨了以下问题：1) 外周动脉疾病（PAD）患者在步行至最大间歇性跛行（IC）后，步行训练（WT）是否会改变心血管负荷；以及 2) 步行的急性和慢性心血管反应是否相互关联：方法：采用随机对照平行组设计。32 名患有 PAD 和 IC 的男性被随机分配到两组中的一组：WT组（n=16）或对照组（CO，n=16），每周两次，为期12周。WT 组完成 15 次、每次 2 分钟的中等强度步行，中间穿插 2 分钟的直立休息。CO 组每次完成 30 分钟的伸展运动。在基线和 12 周后，两组都进行了渐进式步行训练，以达到最大 IC（3.2 公里/小时，每 2 分钟坡度增加 2%）。步行前后测量了收缩压、舒张压、心率和率压乘积。数据采用三方混合方差分析。皮尔逊相关性用于探讨急性和慢性反应之间的关联：结果：WT 能明显降低步行前后的收缩压（P0.05）：结论：在 PAD 患者中，WT 可降低步行至最大 IC 前后的心血管负荷。此外，步行的急性和慢性心血管反应并无关联。因此，WT 可以降低易感患者在步行后立即发生心脏事件的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Problems in Cardiology 医学-心血管系统

CiteScore

4.80

自引率

2.40%

发文量

392

审稿时长

6 days

期刊介绍： Under the editorial leadership of noted cardiologist Dr. Hector O. Ventura, Current Problems in Cardiology provides focused, comprehensive coverage of important clinical topics in cardiology. Each monthly issues, addresses a selected clinical problem or condition, including pathophysiology, invasive and noninvasive diagnosis, drug therapy, surgical management, and rehabilitation; or explores the clinical applications of a diagnostic modality or a particular category of drugs. Critical commentary from the distinguished editorial board accompanies each monograph, providing readers with additional insights. An extensive bibliography in each issue saves hours of library research.