Effect of cumulative uric acid to high-density lipoprotein cholesterol ratio on myocardial infarction in prospective cohorts

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology Pub Date : 2024-10-19 DOI:10.1016/j.cpcardiol.2024.102889

Fan Yang , Jierui Wang , Shouling Wu , Shuohua Chen , Liufu Cui

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引用次数: 0

Abstract

Objective

This study aimed to investigate the effect of the ratio of cumUHR on MI, based on the hypothesis that higher exposure to the ratio of cumUHR is associated with a higher risk of MI.

Methods

Participants who underwent three examinations between 2006 and 2010 were selected. The cumUHR from baseline to the third check was calculated, multiplying the mean between consecutive checks by the time interval between visits. The association between cumUHR and MI and its progression was evaluated by Cox proportional hazards regression model. The cumulative incidence of endpoint events between cumUHR groups was compared using a log-rank test. Stratification by age, sex, and BMI was further performed.

Results

A total of 53,697 people, with an average age of 53.08 years, 78 % of whom were male, with a median follow-up of 10.51 years and 744 myocardial infarction events, were enrolled. The highest cumUHR quartile, MI, had the highest cumulative incidence (log-rank P < 0.01). Multivariate COX regression analysis showed that in the fully adjusted model, there was a high level of concentration in the highest cumUHR quartile (HR, 1.52; 95 % CI, 1.20-1.92) and participants with longer duration of high UHR exposure (HR, 1.55; 95 % CI, 1.22-1.97).

Conclusions

The risk of MI increases with cumUHR and is influenced by the time course of cumUHR. In particular, in people aged ≥ 60 years, males, and BMI < 28 kg/m², the risk of MI is more affected by the level of UHR, and more attention should be paid to controlling the level of UHR.

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前瞻性队列中累积尿酸与高密度脂蛋白胆固醇比率对心肌梗死的影响。

研究目的本研究的目的是基于 "暴露于较高的累积超声心动图比率与较高的心肌梗死风险相关 "这一假设，研究累积超声心动图比率对心肌梗死的影响：方法：选取 2006 年至 2010 年间接受过三次检查的参与者。将连续检查之间的平均值乘以两次检查之间的时间间隔，计算出从基线到第三次检查的累积UHR。通过 Cox 比例危险回归模型评估了 cumUHR 与心肌梗死及其进展之间的关系。采用对数秩检验比较了累积UHR组间终点事件的累积发生率。此外，还根据年龄、性别和体重指数进行了分层：共有 53,697 人参与了研究，平均年龄为 53.08 岁，其中 78% 为男性，中位随访时间为 10.51 年，共发生了 744 起心肌梗死事件。累计心肌梗死发生率最高的是累计心肌梗死发生率最高的四分位数（对数秩PConclusions）：心肌梗死的风险随着累积心肌缺血发生率的增加而增加，并受到累积心肌缺血发生率时间进程的影响。尤其是年龄≥ 60 岁、男性、体重指数（BMI

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Problems in Cardiology 医学-心血管系统

CiteScore

4.80

自引率

2.40%

发文量

392

审稿时长

6 days

期刊介绍： Under the editorial leadership of noted cardiologist Dr. Hector O. Ventura, Current Problems in Cardiology provides focused, comprehensive coverage of important clinical topics in cardiology. Each monthly issues, addresses a selected clinical problem or condition, including pathophysiology, invasive and noninvasive diagnosis, drug therapy, surgical management, and rehabilitation; or explores the clinical applications of a diagnostic modality or a particular category of drugs. Critical commentary from the distinguished editorial board accompanies each monograph, providing readers with additional insights. An extensive bibliography in each issue saves hours of library research.