Impact of High Lipoprotein(a) Levels on Delayed Wound Healing in Patients With Chronic Limb-Threatening Ischemia After Peripheral Endovascular Therapy.

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Circulation Journal Pub Date : 2024-10-19 DOI:10.1253/circj.CJ-24-0383

Yusuke Tomoi, Mitsuyoshi Takahara, Yoshimitsu Soga, Taichi Hirano, Kazuki Tsunoda, Tomonori Katsuki, Kenji Ando

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引用次数: 0

Abstract

Background: Elevated lipoprotein(a) [Lp(a)] levels are a causal risk factor for peripheral artery disease. However, data on their effect on delayed wound healing in patients with chronic limb-threatening ischemia (CLTI) are limited. The present study assessed the association between elevated Lp(a) levels and delayed wound healing in patients with CLTI.

Methods and results: This study included 280 patients who successfully received endovascular therapy for CLTI between September 2016 and August 2021. High Lp(a) levels were defined as those >30 mg/dL. The primary outcome was wound healing. During a median follow-up of 20.4 months (interquartile range 6.8-38.6 months), 146 patients achieved wound healing. The wound healing rate at 24 months was significantly lower in the high Lp(a) than low Lp(a) group (41.1% vs. 86.3%, respectively; P<0.001). The adjusted risk ratio was 0.19 (95% confidence interval 0.13-0.29, P<0.001). Lp(a) levels of 31-50 and >50 mg/dL, but not 16-30 mg/dL, were significantly associated with delayed wound healing relative to Lp(a) levels of ≤15 mg/dL.

Conclusions: Elevated Lp(a) levels were independently associated with delayed wound healing in patients with CLTI treated with endovascular therapy.

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高脂蛋白（a）水平对外周血管治疗后慢性肢体缺血患者伤口延迟愈合的影响

背景：脂蛋白（a）[Lp（a）]水平升高是外周动脉疾病的一个致病危险因素。然而，有关其对慢性肢体缺血（CLTI）患者伤口延迟愈合的影响的数据却很有限。本研究评估了Lp（a）水平升高与CLTI患者伤口延迟愈合之间的关系：本研究纳入了2016年9月至2021年8月期间成功接受血管内治疗的280例CLTI患者。脂蛋白（a）水平过高被定义为>30 mg/dL。主要结果是伤口愈合。在20.4个月的中位随访期间（四分位间范围为6.8-38.6个月），146名患者实现了伤口愈合。高脂蛋白（a）组在24个月时的伤口愈合率明显低于低脂蛋白（a）组（分别为41.1%和86.3%；相对于脂蛋白（a）水平≤15 mg/dL，P50 mg/dL与伤口延迟愈合明显相关，但与16-30 mg/dL无关：结论：Lp(a)水平升高与接受血管内治疗的CLTI患者伤口延迟愈合密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Circulation Journal 医学-心血管系统

CiteScore

5.80

自引率

12.10%

发文量

471

审稿时长

1.6 months

期刊介绍： Circulation publishes original research manuscripts, review articles, and other content related to cardiovascular health and disease, including observational studies, clinical trials, epidemiology, health services and outcomes studies, and advances in basic and translational research.