The effect of botulinum toxin in the masticatory and constrictor musculature of the pharynx as an option in the treatment of obstructive sleep apnea: a case report.

IF 3.5 3区医学 Q1 CLINICAL NEUROLOGY

Journal of Clinical Sleep Medicine Pub Date : 2025-02-01 DOI:10.5664/jcsm.11400

Ana Carolina Xavier Ottoline, Alonço da Cunha Viana, Debora Petrungaro Migueis

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引用次数: 0

Abstract

The botulinum toxin (BT) is United States Food and Drug Administration-approved for therapeutic applications in different medical conditions. However, BT is not considered an obstructive sleep apnea therapy. Obstructive sleep apnea is characterized by recurrent airway collapse during sleep, leading to intermittent hypoxia, hypercapnia, and arousal. The application of BT in pharyngeal and masticatory musculature can reduce its constrictive activity, attenuating the obstructions. We present the first case report of a 38-year-old man with severe obstructive sleep apnea syndrome who underwent a BT infiltration in palatoglossal, stylohyoid, and masseter muscles bilaterally to treat obstructive sleep apnea itself. He had significant clinical and polysomnographic improvement during the muscle afferent block by intramuscular injection of BT, without adverse effects.

Citation: Ottoline ACX, da Cunha Viana A, Migueis DP. The effect of botulinum toxin in the masticatory and constrictor musculature of the pharynx as an option in the treatment of obstructive sleep apnea: a case report. J Clin Sleep Med. 2025;21(2):431-434.

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肉毒杆菌毒素对咽部咀嚼肌和收缩肌的影响，作为治疗阻塞性睡眠呼吸暂停的一种选择：病例报告。

肉毒杆菌毒素（BT）已获得美国食品和药物管理局批准，可用于不同病症的治疗。然而，BT 并不被视为阻塞性睡眠呼吸暂停（OSA）疗法。OSA 的特点是睡眠时气道反复塌陷，导致间歇性缺氧、高碳酸血症和唤醒。对咽部和咀嚼肌应用 BT 可以减少其收缩活动，从而减轻阻塞。我们首次报告了一例患有严重 OSA 综合征的 38 岁男性病例，他在双侧腭舌肌、蝶骨肌和咀嚼肌进行了 BT 浸润，以治疗 OSA 本身。在肌肉注射 BT 进行肌肉传入阻滞期间，他的临床症状和多导睡眠图均有明显改善，且无不良反应。

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来源期刊

Journal of Clinical Sleep Medicine CLINICAL NEUROLOGY-

CiteScore

6.20

自引率

7.00%

发文量

321

审稿时长

1 months

期刊介绍： Journal of Clinical Sleep Medicine focuses on clinical sleep medicine. Its emphasis is publication of papers with direct applicability and/or relevance to the clinical practice of sleep medicine. This includes clinical trials, clinical reviews, clinical commentary and debate, medical economic/practice perspectives, case series and novel/interesting case reports. In addition, the journal will publish proceedings from conferences, workshops and symposia sponsored by the American Academy of Sleep Medicine or other organizations related to improving the practice of sleep medicine.