Association of Physical Activity with Asthma and Chronic Obstructive Pulmonary Disease and Mediation of Frailty: Mendelian Randomization Analyses.

IF 2.7 3区 医学 Q2 RESPIRATORY SYSTEM
Nanxin Chen, Xuejie Si, Jun Wang, Wenjing Chen
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引用次数: 0

Abstract

Background: The existence of an association between physical activity (PA) and asthma and chronic obstructive pulmonary disease (COPD) has been confirmed in observational studies. Therefore, it is necessary to reveal whether there is a risk-effect relationship between physical activity and asthma and COPD through Mendelian randomization (MR) analysis.

Materials and methods: Univariate Mendelian randomization (UVMR) analyses were performed to examine the associations between moderate to vigorous physical activity (MVPA), vigorous physical activity (VPA), accelerometer-assessed physical activity (AA), and strenuous exercise or other exercise (SSOE) with asthma and COPD. The methods of analysis were dominated by Inverse Variance-Weighted (IVW), Weighted median (WM), and MR-Egger methods. In addition, multivariate Mendelian randomization (MVMR) analyses were performed to correct the effects of four types of physical activity on asthma and COPD. Finally, potential mediating effect relationships were identified through mediation analyses.

Results: The results of Univariate Mendelian randomization analysis showed that SSOE could reduce the risk of asthma and COPD(asthma: OR=0.15,95% CI=0.04-0.58, P=0.006; COPD: OR=0.05, 95% CI=0.01-0.33, P=0.002). The results of the Multivariate Mendelian randomization analysis showed that SSOE was still able to reduce the risk of asthma and COPD after adjusting for the effects of different types of physical activity(asthma: 95% CI=-2.77--0.31, P=0.014; COPD: 95% CI=-4.00--0.50, P=0.012). Mediation analyses showed that frailty intervened in the causal relationship between physical activity and asthma and chronic obstructive pulmonary disease.

Conclusion: SSOE is a protective factor for asthma and COPD in the European population, while frailty plays a mediating role.

体育锻炼与哮喘和慢性阻塞性肺病的关系以及对虚弱的调解作用:孟德尔随机分析》。
背景:体力活动(PA)与哮喘和慢性阻塞性肺病(COPD)之间的关系已在观察性研究中得到证实。因此,有必要通过孟德尔随机分析(MR)揭示体育锻炼与哮喘和慢性阻塞性肺病之间是否存在风险效应关系:对中度至剧烈运动(MVPA)、剧烈运动(VPA)、加速度计评估的运动量(AA)、剧烈运动或其他运动(SSOE)与哮喘和慢性阻塞性肺病之间的关系进行了单变量孟德尔随机化(UVMR)分析。分析方法以逆方差加权法(IVW)、加权中位法(WM)和 MR-Egger 法为主。此外,还进行了多变量孟德尔随机化(MVMR)分析,以校正四种体育活动对哮喘和慢性阻塞性肺病的影响。最后,通过中介分析确定了潜在的中介效应关系:结果:单变量孟德尔随机分析结果显示,SSOE 可降低哮喘和慢性阻塞性肺病的发病风险(哮喘:or=0.15,95% COPD:or=0.15,95% COPD:or=0.15):OR=0.15,95% CI=0.04-0.58,P=0.006;COPD:OR=0.05,95% CI=0.01-0.33,P=0.002)。多变量孟德尔随机分析的结果显示,在调整了不同类型体力活动的影响后,SSOE仍能降低哮喘和慢性阻塞性肺病的风险(哮喘:95% CI=-2.77--0.31,P=0.014;慢性阻塞性肺病:95% CI=-4.00--0.50,P=0.012)。中介分析表明,虚弱介入了体育锻炼与哮喘和慢性阻塞性肺病之间的因果关系:结论:在欧洲人群中,SSOE 是哮喘和慢性阻塞性肺病的保护因素,而体弱则起着中介作用。
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来源期刊
CiteScore
4.80
自引率
10.70%
发文量
372
审稿时长
16 weeks
期刊介绍: An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals
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