Association of Tramadol Versus Codeine Prescriptions with all-cause mortality and cardiovascular diseases among patients with osteoarthritis: a systematic review and meta-analysis of propensity score-matched population-based cohort studies.

IF 2 4区 医学 Q3 RHEUMATOLOGY
Mansour Bahardoust, Sepideh Mousavi, Maryam Zolfaghari Dehkharghani, Mahsa Arab, Heeva Rashidi, Habib Gorgani, Meisam Haghmoradi, Alireza Askari
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Abstract

Background: Today, the prescription of tramadol in patients with osteoarthritis (OA) has increased significantly, which can be associated with serious consequences. Contradictory results have been reported regarding the association of tramadol versus codeine with the risk of all-cause mortality (ACM) and cardiovascular diseases (CVD).

Methods: This systematic review and meta-analysis aimed to evaluate, for the first time, the association of tramadol versus codeine with the risk of ACM and CVD in OA patients for the first time. We searched PubMed, Scopus, Embase, Web of sciences, and Google Scholar with specific keywords and mesh terms to find relevant studies until January 2024. Two independent researchers did the process of searching and screening articles. Cochran's Q and I2 tests evaluated the heterogeneity of the studies. Egger's test was used to evaluate the existence of publication bias.

Results: Seven population-based cohort studies, matched by the propensity score method, including 1,939,293 participants, were reviewed. The study pooled results did not show a significant association between the prescriptions of tramadol versus codeine with increasing the risk of ACM in OA patients. (Hazard ratio (HR): 1.084, 95% confidence interval (95%) CI: 0.883, 1.286, P: 0.56) In addition, the prescription of tramadol versus codeine was not associated with an increased risk of CVD in OA. (HR: 1.025, 95% CI: 0.89, 1.16, P: 0.68, I2 = 37.8%) CONCLUSION: Our systematic review showed that tramadol prescription compared to codeine in OA patients was not associated with an increased risk of ACM and CVD.

曲马多与可待因处方与骨关节炎患者全因死亡率和心血管疾病的关系:对倾向得分匹配人群队列研究的系统回顾和荟萃分析。
背景:如今,骨关节炎(OA)患者的曲马多处方大幅增加,这可能会带来严重后果。关于曲马多和可待因与全因死亡率(ACM)和心血管疾病(CVD)风险的关系,已有相互矛盾的结果报道:本系统综述和荟萃分析旨在首次评估曲马多与可待因与 OA 患者全因死亡率(ACM)和心血管疾病(CVD)风险的关系。我们使用特定的关键词和网状术语检索了 PubMed、Scopus、Embase、Web of sciences 和 Google Scholar,以查找 2024 年 1 月之前的相关研究。两名独立研究人员负责搜索和筛选文章。Cochran's Q 和 I2 检验评估了研究的异质性。Egger检验用于评估是否存在发表偏倚:共审查了七项基于人群的队列研究,这些研究采用倾向得分法进行配对,包括 1,939,293 名参与者。研究汇总结果显示,曲马多处方与可待因处方在增加 OA 患者 ACM 风险方面没有明显关联。(危险比(HR):1.084,95% 置信区间(95%)CI:0.883,1.286,P:0.56)此外,曲马多与可待因的处方与 OA 患者心血管疾病风险的增加也没有关系。(HR:1.025,95% CI:0.89,1.16,P:0.68,I2 = 37.8%)结论:我们的系统综述显示,与可待因相比,OA 患者的曲马多处方与 ACM 和心血管疾病风险增加无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advances in Rheumatology
Advances in Rheumatology Medicine-Rheumatology
CiteScore
4.00
自引率
4.30%
发文量
41
审稿时长
53 weeks
期刊介绍: Formerly named Revista Brasileira de Reumatologia, the journal is celebrating its 60th year of publication. Advances in Rheumatology is an international, open access journal publishing pre-clinical, translational and clinical studies on all aspects of paediatric and adult rheumatic diseases, including degenerative, inflammatory and autoimmune conditions. The journal is the official publication of the Brazilian Society of Rheumatology and welcomes original research (including systematic reviews and meta-analyses), literature reviews, guidelines and letters arising from published material.
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