Role of patatin-like phospholipase domain-containing 3 gene for decreasing kidney function in recently diagnosed diabetes mellitus

IF 4.3 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-10-01 DOI:10.1016/j.dsx.2024.103137

Oana Patricia Zaharia , Klaus Strassburger , Birgit Knebel , Christian Binsch , Yuliya Kupriyanova , Clara Möser , Kálmán Bódis , Katsiaryna Prystupa , Iryna Yurchenko , Dania Marel Mendez Cardenas , Martin Schön , Christian Herder , Hadi Al-Hasani , Vera Schrauwen-Hinderling , Karin Jandeleit-Dahm , Robert Wagner , Michael Roden , GDS Group

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Abstract

Aims

We examined the association of the G allele in the single-nucleotide polymorphism (SNP) rs738409 in the third exon of patatin-like phospholipase domain-containing 3 gene (PNPLA3) gene, with chronic kidney disease in diabetes endotypes.

Methods

Participants with recent-onset diabetes (n = 707) from the prospective German Diabetes Study (GDS) underwent cluster assignment, detailed phenotyping, genotyping and magnetic resonance spectroscopy to quantify hepatocellular lipid content (HCL).

Results

Severe insulin-resistant diabetes (SIRD) had the lowest glomerular filtration rates (eGFR) and highest HCL compared to severe insulin-deficient, moderate obesity-related, moderate age-related and severe autoimmune diabetes endotypes (all p < 0.05). HCL was negatively associated with eGFR (r = −0.287, p < 0.01) across all groups. Stratification by G-allele carrier status did not reveal any association between HCL and eGFR among the endotypes. However, the proportion of G-allele carriers increased from 44 % for eGFR >60 ml/min to 52 % for eGFR <60 ml/min (p < 0.05).

Conclusions

The PNPLA3 polymorphism may contribute to declining kidney function independently of liver lipids.

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含拍蛋白样磷脂酶域的 3 基因在降低新诊断糖尿病患者肾功能中的作用

目的：我们研究了单核苷酸多态性（SNP）rs738409中的G等位基因与糖尿病内型中慢性肾脏疾病的关系：方法：对前瞻性德国糖尿病研究（GDS）中新近发病的糖尿病患者（n = 707）进行分组、详细表型分析、基因分型和磁共振波谱分析，以量化肝细胞脂质含量（HCL）：结果：与重度胰岛素缺乏、中度肥胖相关、中度年龄相关和重度自身免疫性糖尿病内型相比，重度胰岛素抵抗性糖尿病（SIRD）的肾小球滤过率（eGFR）最低，HCL最高（eGFR结论均为60毫升/分钟至52%）：PNPLA3多态性可能会导致肾功能下降，而与肝脏血脂无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Metabolic Syndrome-Clinical Research & Reviews ENDOCRINOLOGY & METABOLISM-

CiteScore

22.90

自引率

2.00%

发文量

248

审稿时长

51 days

期刊介绍： Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.