Role of patatin-like phospholipase domain-containing 3 gene for decreasing kidney function in recently diagnosed diabetes mellitus

IF 4.3 Q1 ENDOCRINOLOGY & METABOLISM
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引用次数: 0

Abstract

Aims

We examined the association of the G allele in the single-nucleotide polymorphism (SNP) rs738409 in the third exon of patatin-like phospholipase domain-containing 3 gene (PNPLA3) gene, with chronic kidney disease in diabetes endotypes.

Methods

Participants with recent-onset diabetes (n = 707) from the prospective German Diabetes Study (GDS) underwent cluster assignment, detailed phenotyping, genotyping and magnetic resonance spectroscopy to quantify hepatocellular lipid content (HCL).

Results

Severe insulin-resistant diabetes (SIRD) had the lowest glomerular filtration rates (eGFR) and highest HCL compared to severe insulin-deficient, moderate obesity-related, moderate age-related and severe autoimmune diabetes endotypes (all p < 0.05). HCL was negatively associated with eGFR (r = −0.287, p < 0.01) across all groups. Stratification by G-allele carrier status did not reveal any association between HCL and eGFR among the endotypes. However, the proportion of G-allele carriers increased from 44 % for eGFR >60 ml/min to 52 % for eGFR <60 ml/min (p < 0.05).

Conclusions

The PNPLA3 polymorphism may contribute to declining kidney function independently of liver lipids.
含拍蛋白样磷脂酶域的 3 基因在降低新诊断糖尿病患者肾功能中的作用
目的:我们研究了单核苷酸多态性(SNP)rs738409中的G等位基因与糖尿病内型中慢性肾脏疾病的关系:方法:对前瞻性德国糖尿病研究(GDS)中新近发病的糖尿病患者(n = 707)进行分组、详细表型分析、基因分型和磁共振波谱分析,以量化肝细胞脂质含量(HCL):结果:与重度胰岛素缺乏、中度肥胖相关、中度年龄相关和重度自身免疫性糖尿病内型相比,重度胰岛素抵抗性糖尿病(SIRD)的肾小球滤过率(eGFR)最低,HCL最高(eGFR结论均为60毫升/分钟至52%):PNPLA3多态性可能会导致肾功能下降,而与肝脏血脂无关。
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来源期刊
CiteScore
22.90
自引率
2.00%
发文量
248
审稿时长
51 days
期刊介绍: Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.
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