Unraveling the interplay between inflammation and stem cell mobilization or homing: Implications for tissue repair and therapeutics.

IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL
Tzu Chi Medical Journal Pub Date : 2024-09-05 eCollection Date: 2024-10-01 DOI:10.4103/tcmj.tcmj_100_24
Hsin-Hou Chang, Yu-Shan Liou, Der-Shan Sun
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引用次数: 0

Abstract

Inflammation and stem cell mobilization or homing play pivotal roles in tissue repair and regeneration. This review explores their intricate interplay, elucidating their collaborative role in maintaining tissue homeostasis and responding to injury or disease. While examining the fundamentals of stem cells, we detail the mechanisms underlying inflammation, including immune cell recruitment and inflammatory mediator release, highlighting their self-renewal and differentiation capabilities. Central to our exploration is the modulation of hematopoietic stem cell behavior by inflammatory cues, driving their mobilization from the bone marrow niche into circulation. Key cytokines, chemokines, growth factors, and autophagy, an intracellular catabolic mechanism involved in this process, are discussed alongside their clinical relevance. Furthermore, mesenchymal stem cell homing in response to inflammation contributes to tissue repair processes. In addition, we discuss stem cell resilience in the face of inflammatory challenges. Moreover, we examine the reciprocal influence of stem cells on the inflammatory milieu, shaping immune responses and tissue repair. We underscore the potential of targeting inflammation-induced stem cell mobilization for regenerative therapies through extensive literature analysis and clinical insights. By unraveling the complex interplay between inflammation and stem cells, this review advances our understanding of tissue repair mechanisms and offers promising avenues for clinical translation in regenerative medicine.

揭示炎症与干细胞动员或归巢之间的相互作用:对组织修复和治疗的影响。
炎症和干细胞动员或归巢在组织修复和再生中发挥着关键作用。这篇综述探讨了它们之间错综复杂的相互作用,阐明了它们在维持组织稳态和应对损伤或疾病方面的协同作用。在研究干细胞基本原理的同时,我们详细介绍了炎症的内在机制,包括免疫细胞招募和炎症介质释放,突出了干细胞的自我更新和分化能力。我们探索的核心是炎症线索对造血干细胞行为的调控,推动其从骨髓龛动员进入血液循环。我们讨论了关键的细胞因子、趋化因子、生长因子和自噬(参与这一过程的细胞内分解代谢机制),以及它们的临床意义。此外,间充质干细胞因炎症而归巢也有助于组织修复过程。此外,我们还讨论了干细胞面对炎症挑战时的恢复能力。此外,我们研究了干细胞对炎症环境的相互影响,从而形成免疫反应和组织修复。我们通过广泛的文献分析和临床见解,强调了针对炎症诱导的干细胞动员进行再生治疗的潜力。通过揭示炎症与干细胞之间复杂的相互作用,这篇综述加深了我们对组织修复机制的理解,并为再生医学的临床转化提供了前景广阔的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Tzu Chi Medical Journal
Tzu Chi Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
3.40
自引率
0.00%
发文量
44
审稿时长
13 weeks
期刊介绍: The Tzu Chi Medical Journal is the peer-reviewed publication of the Buddhist Compassion Relief Tzu Chi Foundation, and includes original research papers on clinical medicine and basic science, case reports, clinical pathological pages, and review articles.
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