Effectiveness and Tolerability of Various 5-Fluorouracil Formulations as Adjuvant Therapies for Vitiligo Management: A Systematic Review and Meta-Analysis.

IF 1.3 Q4 PHARMACOLOGY & PHARMACY
Neveen A Kohaf, Sameh M Sarsik, Samar Salman, Omnya M Amin
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Abstract

Background: All vitiligo treatments are restricted, and no known treatment reliably produces repigmentation. In this study, we investigated the efficacy and safety of 5-Fluorouracil (5FU) as adjuvant therapy in treating vitiligo.

Method: Using five significant databases, an electronic systematic search of the literature was conducted. Randomized Clinical Trials (RCTs) that investigated 5FU for treating vitiligo in humans were selected for a meta-analysis and systematic review. This study was conducted by following PROSPERO (CRD42022345736).

Results: A total of 10 studies involving 302 patients were included in our systematic review. The meta-analysis of eight studies revealed that the combination of 5FU with microneedling showed a statistically significant superior effect in comparison with other treatment modalities in ing >75% repigmentation (OR= 4.47; 95%CI= (2.39, 8.35), P < 0.00001). 5FU with microneedling versus microneedling alone showed higher efficacy of 5FU with statistically significant results (OR= 4.22; 95%CI= (1.55, 11.44), P= 0.005). Regarding the influence of different formulations of 5FU, the meta-regression revealed that the highest efficacy was achieved when microneedling was combined with liposomal formulations. There were not any reported severe side effects related to 5FU.

Conclusion: 5FU as an adjuvant treatment for vitiligo was found to be more effective in achieving ≥75% repigmentation rates.

各种5-氟尿嘧啶制剂作为白癜风辅助疗法的有效性和耐受性:系统回顾与元分析》。
背景:所有的白癜风治疗方法都受到限制,没有一种已知的治疗方法能可靠地产生再色素沉着。在这项研究中,我们调查了5-氟尿嘧啶(5FU)作为辅助疗法治疗白癜风的有效性和安全性:方法:利用五个重要数据库对文献进行了电子系统检索。方法:使用五个重要数据库对文献进行了电子系统检索,选择了研究 5FU 治疗人类白癜风的随机临床试验 (RCT) 进行荟萃分析和系统综述。本研究按照 PROSPERO (CRD42022345736) 进行:我们的系统综述共纳入了 10 项研究,涉及 302 名患者。8项研究的荟萃分析表明,5FU与微针联合治疗与其他治疗方式相比,在色素沉着率大于75%方面具有显著的统计学优势(OR= 4.47; 95%CI= (2.39, 8.35), P < 0.00001)。5FU配合微针疗法与单独使用微针疗法相比,5FU的疗效更高,且具有统计学意义(OR= 4.22;95%CI= (1.55,11.44),P= 0.005)。关于 5FU 不同制剂的影响,元回归显示,微针疗法与脂质体制剂结合使用时疗效最高。没有任何与5FU相关的严重副作用的报道。结论:5FU作为白癜风的辅助治疗,能更有效地达到≥75%的色素再形成率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.80
自引率
9.10%
发文量
55
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