Genomic and transcriptomic evaluations of infertile or subfertile Arunachali yak sperm.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-17 DOI:10.1017/S0967199424000194

Pranab Jyoti Das, Aneet Kour, Jyotika Bhati, Dwijesh Chandra Mishra, Mihir Sarkar

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引用次数: 0

Abstract

Sperm infertility or subfertility is detrimental to the precious highland germplasm like yak whose population has been gradually declining in India. Understanding the 'omic' landscape of infertile or subfertile yak sperm can reveal some interesting insights. In an attempt to do the same, this study considered the semen of infertile or subfertile yak bulls for whole-genome and transcriptome evaluations. DNA sequencing revealed that the yak sperm genome contains the necessary genes to carry out all the important biological processes related to the growth, development, survival and multiplication of an organism. Interestingly, RNA Seq results highlighted that genes like VAMP7, MYLK, ARAP2 and MARCH6 showed increased expression, while biological processes related to immune response (GO:0043308, GO:0002447, GO:0002278, GO:0043307, GO:0043312, GO:0002283, GO:0043299 and GO:0002446) were significantly overrepresented. These findings hint at a possible role played by immune system in regulating infertility or subfertility in yaks. Further, in-depth studies can validate these findings and help in improving our biological understanding in this area.

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不育或亚不育阿鲁纳恰里牦牛精子的基因组和转录组评估。

精子不育或亚不育对印度牦牛等珍贵的高原种质不利，因为印度牦牛的数量正在逐渐减少。了解不育或亚不育牦牛精子的 "奥米克 "图谱可以揭示一些有趣的见解。为了实现这一目标，本研究对不育或亚育牦牛的精液进行了全基因组和转录组评估。DNA 测序结果表明，牦牛精子基因组包含了与生物体的生长、发育、存活和繁殖有关的所有重要生物过程所需的基因。有趣的是，RNA Seq结果表明，VAMP7、MYLK、ARAP2和MARCH6等基因的表达量有所增加，而与免疫反应有关的生物过程（GO:0043308、GO:0002447、GO:0002278、GO:0043307、GO:0043312、GO:0002283、GO:0043299和GO:0002446）的代表性明显偏高。这些发现暗示了免疫系统在调节牦牛不育或亚不育中可能扮演的角色。进一步的深入研究可以验证这些发现，并有助于提高我们对这一领域的生物学认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.