[Advances in the application of liquid chromatography tandem mass spectrometry for therapeutic drug monitoring].

Q3 Medicine

中华预防医学杂志 Pub Date : 2024-10-06 DOI:10.3760/cma.j.cn112150-20240419-00328

J X Liu, W Guo

引用次数: 0

Abstract

Therapeutic drug monitoring is a good interpretation of personalized medicine, which helps to improve the safety and effectiveness of patient medication. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has gradually been widely accepted by clinical laboratories due to its characteristics of specificity, sensitivity, and flexibility in method development. This article introduces the importance and analytical techniques for therapeutic drug monitoring, describes the application and development of liquid chromatography tandem mass spectrometry for therapeutic drug monitoring, new advances in the detection of different drug types and sample types, and challenges in automation, convenience, and standardization.

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[液相色谱串联质谱法在治疗药物监测中的应用进展]。

治疗药物监测是对个性化医疗的很好诠释，有助于提高患者用药的安全性和有效性。液相色谱-串联质谱（LC-MS/MS）以其特异性强、灵敏度高、方法开发灵活等特点逐渐被临床实验室广泛接受。本文介绍了治疗药物监测的重要性和分析技术，阐述了液相色谱-串联质谱法在治疗药物监测中的应用和发展，不同药物类型和样品类型检测的新进展，以及在自动化、便利性和标准化方面的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中华预防医学杂志 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

12678

期刊介绍： Chinese Journal of Preventive Medicine (CJPM), the successor to Chinese Health Journal , was initiated on October 1, 1953. In 1960, it was amalgamated with the Chinese Medical Journal and the Journal of Medical History and Health Care , and thereafter, was renamed as People’s Care . On November 25, 1978, the publication was denominated as Chinese Journal of Preventive Medicine . The contents of CJPM deal with a wide range of disciplines and technologies including epidemiology, environmental health, nutrition and food hygiene, occupational health, hygiene for children and adolescents, radiological health, toxicology, biostatistics, social medicine, pathogenic and epidemiological research in malignant tumor, surveillance and immunization.