Efficacy and Safety of Low-Density Pedicle Screw versus High-Density Screw in Lenke I Scoliosis: A Systematic Review and Meta-Analysis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-11-04 DOI:10.1016/j.wneu.2024.10.029

Zhe Qiang, Qiang Zhou, Xuanwen Liu, Bin Zheng

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引用次数: 0

Abstract

Objective: To evaluate the efficacy and safety of low-density versus high-density pedicle screw in patients with Lenke I adolescent idiopathic scoliosis through systematic review and meta-analysis.

Methods: A comprehensive literature search was conducted in PubMed, Web of Science, and Embase databases. Studies comparing low-density and high-density pedicle screw in Lenke I adolescent idiopathic scoliosis were included. Two authors independently selected studies, assessed risk of bias, and extracted data. Meta-analysis was performed using systematic review software.

Results: The meta-analysis included 11 studies comprising 697 patients (397 in low-density group and 300 in high-density group). No significant differences were found between low-density and high-density groups in terms of blood loss, operative time, complication rates, or revision rates. Radiographic outcomes, including major Cobb angle, curve correction, thoracic kyphosis, and coronal and sagittal balance, were also similar between the groups. However, low-density pedicle screw was associated with significantly lower costs.

Conclusions: This meta-analysis suggests that low-density pedicle screw can achieve similar clinical and radiographic outcomes compared with high-density constructs in patients with Lenke I adolescent idiopathic scoliosis, while potentially reducing costs, making it a more cost-effective option without compromising patient outcomes.

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低密度椎弓根螺钉与高密度螺钉在伦克I型脊柱侧凸中的疗效和安全性对比：系统回顾与荟萃分析。

研究背景本研究旨在通过系统综述和荟萃分析，评估低密度椎弓根螺钉与高密度椎弓根螺钉在伦克I型AIS患者中的疗效和安全性：在PubMed、Web of Science和Embase数据库中进行了全面的文献检索。方法：在PubM、Web Science和Embed数据库中进行了全面的文献检索，纳入了在Lenke I型AIS患者中比较低密度和高密度椎弓根螺钉的研究。两位作者独立筛选研究、评估偏倚风险并提取数据。使用RevMan 5.4软件进行Meta分析：共纳入了 11 项研究，涉及 697 名患者（低密度组 397 人，高密度组 300 人）。Meta 分析表明，低密度组和高密度组在失血量、手术时间、并发症发生率或翻修率方面没有明显差异。两组的影像学结果（包括主要 Cobb 角、曲线矫正、胸椎后凸、冠状面和矢状面平衡）也相似。然而，低密度组的成本明显更低：这项荟萃分析表明，与高密度椎弓根螺钉相比，低密度椎弓根螺钉可为 Lenke I 型 AIS 患者带来相似的临床和影像学效果，同时还可能降低成本，因此是一种更具成本效益的选择，且不会影响患者的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.