AVR/I/SSAPDB: a comprehensive & specialised knowledgebase of antimicrobial peptides to combat VRSA, VISA, and VSSA.

IF 4 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

World journal of microbiology & biotechnology Pub Date : 2024-10-15 DOI:10.1007/s11274-024-04162-0

Rajat Kumar Mondal, Debayan Karmakar, Oshin Pal, Sintu Kumar Samanta

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引用次数: 0

Abstract

The rise of multi-drug resistant (MDR) bacteria, especially strains of Staphylococcus aureus like Vancomycin-resistant S. aureus (VRSA), Vancomycin-intermediate S. aureus (VISA), and Vancomycin-susceptible S. aureus (VSSA), poses a severe threat to global health. This situation underscores the urgent need for novel antimicrobial agents to combat these resistant strains effectively. Here, we are introducing the Anti-Vancomycin-Resistant/Intermediate/Susceptible Staphylococcus aureus Peptide Database (AVR/I/SSAPDB), a manually curated comprehensive and specialised knowledgebase dedicated to antimicrobial peptides (AMPs) that target VRSA, VISA, and VSSA with clinical and non-clinical significance. Our database sources data from PubMed, cataloging 491 experimentally validated AMPs with detailed annotations on peptides, activity, and cross-references to external databases like PubMed, UniProt, PDB, and DrugBank. AVR/I/SSAPDB offers a user-friendly interface with simple to advanced and list-based search capabilities, enabling researchers to explore AMPs against VRSA, VISA, and VSSA. We are hoping that this resource will be helpful to the scientific community in developing targeted peptide-based therapeutics, providing a crucial tool for combating VRSA, VISA, and VSSA, and addressing a major public health concern. AVR/I/SSAPDB is freely accessible via any web-browser at URL: https://bblserver.org.in/avrissa/ .

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AVR/I/SSAPDB：全面而专业的抗菌肽知识库，用于对抗 VRSA、VISA 和 VSSA。

耐多药（MDR）细菌，尤其是耐万古霉素金黄色葡萄球菌（VRSA）、万古霉素中间型金黄色葡萄球菌（VISA）和万古霉素易感金黄色葡萄球菌（VSSA）等金黄色葡萄球菌菌株的增多，对全球健康构成了严重威胁。这种情况突出表明，迫切需要新型抗菌药物来有效对抗这些耐药菌株。在此，我们将介绍抗万古霉素耐药/中型/易感金黄色葡萄球菌多肽数据库（AVR/I/SSAPDB），这是一个经人工编辑的全面而专业的知识库，专门收集针对 VRSA、VISA 和 VSSA 的抗菌肽（AMPs），具有临床和非临床意义。我们的数据库数据来源于 PubMed，收录了 491 种经过实验验证的 AMPs，其中包含有关肽、活性的详细注释，以及与 PubMed、UniProt、PDB 和 DrugBank 等外部数据库的交叉引用。AVR/I/SSAPDB 提供了一个用户友好型界面，具有从简单到高级以及基于列表的搜索功能，使研究人员能够根据 VRSA、VISA 和 VSSA 探索 AMPs。我们希望这一资源将有助于科学界开发基于多肽的靶向治疗药物，为抗击 VRSA、VISA 和 VSSA 提供重要工具，并解决重大公共卫生问题。AVR/I/SSAPDB 可通过任何网络浏览器免费访问，网址是：https://bblserver.org.in/avrissa/ 。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World journal of microbiology & biotechnology 工程技术-生物工程与应用微生物

CiteScore

6.30

自引率

2.40%

发文量

257

审稿时长

2.5 months

期刊介绍： World Journal of Microbiology and Biotechnology publishes research papers and review articles on all aspects of Microbiology and Microbial Biotechnology. Since its foundation, the Journal has provided a forum for research work directed toward finding microbiological and biotechnological solutions to global problems. As many of these problems, including crop productivity, public health and waste management, have major impacts in the developing world, the Journal especially reports on advances for and from developing regions. Some topics are not within the scope of the Journal. Please do not submit your manuscript if it falls into one of the following categories: · Virology · Simple isolation of microbes from local sources · Simple descriptions of an environment or reports on a procedure · Veterinary, agricultural and clinical topics in which the main focus is not on a microorganism · Data reporting on host response to microbes · Optimization of a procedure · Description of the biological effects of not fully identified compounds or undefined extracts of natural origin · Data on not fully purified enzymes or procedures in which they are applied All articles published in the Journal are independently refereed.