Comparative and experimental pathology of passaged Newcastle disease virus isolates in ducks.

IF 2.3 2区农林科学 Q2 PATHOLOGY

Veterinary Pathology Pub Date : 2024-10-19 DOI:10.1177/03009858241286817

Sohta Hishikawa, Yuji Sunden, Aoi Imamura, Chiharu Hidaka, Hiroshi Ito, Toshihiro Ito, Takehito Morita

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引用次数: 0

Abstract

Although waterfowl are less susceptible to Newcastle disease (ND) virus (NDV) infection compared with chickens and turkeys, lethal ND in waterfowl has been sporadically reported. Factors underlying the high pathogenicity of certain NDV strains in waterfowl remain unclear. In ducks, the NDV 9a5b isolate shows low pathogenicity while the d5a20b isolate shows high pathogenicity. This study aimed to identify the definitive lesions that led to the lethal virulence of d5a20b by comparing the histopathology of 9a5b- or d5a20b-inoculated ducks in order to elucidate lesions related to the enhanced pathogenicity of certain NDV strains in ducks. Herein, 7-day-old ducks were intranasally inoculated with either 9a5b or d5a20b NDV strains. The neurological signs were more severe in the d5a20b-inoculated group than in the 9a5b-inoculated group. Ducks in the d5a20b-inoculated group exhibited more severe lymphoid depletion in immune organs than those in the 9a5b-inoculated group, which may have caused an immunosuppressive state in the d5a20b-inoculated ducks. Ducks in the d5a20b-inoculated group had more severe nonsuppurative encephalitis with increased NDV nucleoprotein than those in the 9a5b-inoculated group. Additionally, pancreatic necrosis, with intralesional NDV nucleoprotein, was more severe in the d5a20b-inoculated group than in the 9a5b-inoculated group. Our results showed that the immune organs, brain, and pancreas were significant targets of the NDV d5a20b infection in ducks.

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鸭新城疫病毒分离株的病理比较和实验。

尽管与鸡和火鸡相比，水禽对新城疫病毒（NDV）感染的易感性较低，但水禽感染致死性新城疫病毒的报道仍时有发生。某些 NDV 株系在水禽中具有高致病性的原因尚不清楚。在鸭中，NDV 9a5b 株系表现出低致病性，而 d5a20b 株系则表现出高致病性。本研究旨在通过比较接种 9a5b 或 d5a20b 的鸭子的组织病理学，确定导致 d5a20b 致命致病性的明确病变，从而阐明与某些 NDV 株系在鸭中致病性增强有关的病变。在此，给 7 日龄的鸭子鼻内接种 9a5b 或 d5a20b NDV 株系。d5a20b接种组的神经症状比9a5b接种组更严重。d5a20b 接种组的鸭子比 9a5b 接种组的鸭子表现出更严重的免疫器官淋巴细胞耗竭，这可能导致了 d5a20b 接种组鸭子的免疫抑制状态。与 9a5b 接种组相比，d5a20b 接种组的鸭子患有更严重的非化脓性脑炎，NDV 核蛋白增加。此外，d5a20b接种组的胰腺坏死比9a5b接种组更为严重，且胰腺内有NDV核蛋白。我们的研究结果表明，免疫器官、大脑和胰腺是鸭感染 NDV d5a20b 的重要目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary Pathology 农林科学-病理学

CiteScore

4.70

自引率

8.30%

发文量

审稿时长

2 months

期刊介绍： Veterinary Pathology (VET) is the premier international publication of basic and applied research involving domestic, laboratory, wildlife, marine and zoo animals, and poultry. Bridging the divide between natural and experimental diseases, the journal details the diagnostic investigations of diseases of animals; reports experimental studies on mechanisms of specific processes; provides unique insights into animal models of human disease; and presents studies on environmental and pharmaceutical hazards.