Liver transplantation improves erectile function in patients with end-stage liver disease: a systematic review and meta-analysis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-30 Epub Date: 2024-09-26 DOI:10.21037/tau-24-185

Yangyang Mei, Xiaogang Wang, Yangmeina Li, Renfang Xu, Xingliang Feng

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引用次数: 0

Abstract

Background: Liver transplantation (LT) has been recognized as the most effective therapy for end-stage liver disease (ESLD). However, the question of whether LT can improve erectile function in patients with ESLD remains controversial. Therefore, we conducted this meta-analysis to evaluate the association between LT and erectile dysfunction (ED).

Methods: According to the PRISMA guidelines, studies were included after conducting searches in four databases from March 2024 onwards. These databases included PubMed, Cochrane Library, Web of Science, and Embase. The primary outcome of interest was to compare the International Index of Erectile Function (IIEF) scores between patients after and before LT. Standardized mean differences (SMDs) and their corresponding 95% confidence intervals (CIs) were utilized to assess the relationship between LT and ED.

Results: The results showed that the LT group had higher IIEF-5 domain scores for erectile function compared to the control group (SMD =-0.31, 95% CI: -0.53 to -0.09), P=0.007). No heterogeneity or publication bias was detected in the results. Additionally, the IIEF-15 domain score was also found to be improved after LT. Specifically, the LT group had higher domain scores for erectile function (SMD =-0.77, 95% CI: -1.07 to -0.48, P<0.001), orgasmic function (SMD =-0.82, 95% CI: -1.12 to -0.52, P<0.001), sexual desire (SMD =-0.89, 95% CI: -1.19 to -0.59, P<0.001), intercourse satisfaction (SMD =-0.92, 95% CI: -1.22 to -0.62, P<0.001), and overall satisfaction (SMD =-0.87, 95% CI: -1.17 to -0.57, P<0.001).

Conclusions: It is suggested by our meta-analysis that LT may contribute to improvements in erectile function among men with ESLD. This improvement may be related to the remarkable improvement in endocrine hormone disorders observed after LT. However, future studies with better designs and larger sample sizes are still needed to confirm our conclusions. Additionally, attention to erectile function before and after surgery in patients with liver failure is crucial.

查看原文本刊更多论文

肝移植可改善终末期肝病患者的勃起功能：系统回顾和荟萃分析。

背景：肝移植（LT）已被公认为是治疗终末期肝病（ESLD）最有效的疗法。然而，LT能否改善ESLD患者的勃起功能这一问题仍存在争议。因此，我们进行了这项荟萃分析，以评估LT与勃起功能障碍（ED）之间的关系：根据 PRISMA 指南，从 2024 年 3 月起在四个数据库中进行检索后纳入了相关研究。这些数据库包括 PubMed、Cochrane Library、Web of Science 和 Embase。主要研究结果是比较LT前后患者的国际勃起功能指数（IIEF）得分。采用标准化平均差（SMDs）及其相应的95%置信区间（CIs）来评估LT与ED之间的关系：结果显示，与对照组相比，LT组的勃起功能IIEF-5域得分更高（SMD =-0.31, 95% CI: -0.53 to -0.09），P=0.007）。研究结果未发现异质性或发表偏差。此外，IIEF-15领域得分在LT后也有所改善。具体而言，LT 组的勃起功能域得分更高（SMD =-0.77，95% CI：-1.07 至-0.48，PC 结论：我们的荟萃分析表明，LT可能有助于改善ESLD男性患者的勃起功能。这种改善可能与 LT 后观察到的内分泌激素紊乱的显著改善有关。然而，要证实我们的结论，仍需要未来设计更好、样本量更大的研究。此外，关注肝衰竭患者手术前后的勃起功能也至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.