Association of chronic constipation and chronic diarrhea with renal stones: a cross-sectional study of the National Health and Nutrition Examination Survey 2007-2010.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-30 Epub Date: 2024-09-26 DOI:10.21037/tau-24-212

Sikui Shen, Xingpeng Di, Liyuan Xiang, Hong Li, Banghua Liao

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引用次数: 0

Abstract

Background: Renal stone is a highly prevalent life-long disease with a high recurrence rate. Chronic bowel diseases, including chronic gastrointestinal symptoms (chronic constipation or chronic diarrhea), are common gastrointestinal problems. We aimed to evaluate the associations of chronic constipation and chronic diarrhea with renal stones.

Methods: This large-scale, cross-sectional study was performed within participants (≥20 years old) from the National Health and Nutrition Examination Survey from 2007 to 2010. Logistic regression and sensitivity analyses were conducted to clarify the association between chronic bowel diseases and renal stones.

Results: A total of 8,067 participants aged ≥20 years were included. The prevalence of renal stones is 9.14%. Chronic diarrhea was positively related to the risk of renal stones [odds ratio (OR) =1.681, 95% confidence interval (CI): 1.212 to 2.330, P=0.004] after adjusting for all covariates. In participants with body mass index (BMI) over 30 kg/m², chronic constipation was correlated with kidney stones in fully adjusted model 2 (OR =2.142, 95% CI: 1.389 to 3.303, P=0.004).

Conclusions: Our findings provide evidence that chronic diarrhea is associated with an increased risk of renal stones. Chronic constipation is positively related to the risk of renal stones in participants with BMI over 30 kg/m². Health care should focus more on bowel health status for the prevention of related diseases. More prospective cohort studies are needed.

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慢性便秘和慢性腹泻与肾结石的关系：2007-2010 年全国健康与营养调查横断面研究。

背景：肾结石是一种高发的终身性疾病，复发率很高。慢性肠道疾病，包括慢性胃肠道症状（慢性便秘或慢性腹泻），是常见的胃肠道问题。我们旨在评估慢性便秘和慢性腹泻与肾结石的关系：这项大规模的横断面研究是在2007年至2010年全国健康与营养调查的参与者（≥20岁）中进行的。为了明确慢性肠道疾病与肾结石之间的关系，我们进行了逻辑回归和敏感性分析：结果：共纳入了8067名年龄≥20岁的参与者。肾结石发病率为 9.14%。调整所有协变量后，慢性腹泻与肾结石风险呈正相关[几率比（OR）=1.681，95% 置信区间（CI）：1.212 至 2.330，P=0.004]。在体重指数（BMI）超过 30 kg/m2 的参与者中，慢性便秘与肾结石在完全调整模型 2 中具有相关性（OR =2.142，95% CI：1.389 至 3.303，P=0.004）：我们的研究结果提供了慢性腹泻与肾结石风险增加相关的证据。在体重指数超过 30 kg/m2 的参与者中，慢性便秘与肾结石风险呈正相关。医疗保健应更加关注肠道健康状况，以预防相关疾病。需要进行更多的前瞻性队列研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.