Absence of dysregulation in amplitude and phase of circadian rhythm of core body temperature in idiopathic hypersomnia: A case-control study.

IF 5.6 2区医学 Q1 Medicine

Sleep Pub Date : 2024-10-21 DOI:10.1093/sleep/zsae246

Tugdual Adam, Lucie Barateau, Jérôme Tanty, Yves Dauvilliers

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Abstract

Study objectives: To investigate amplitude and phase of the circadian rhythm of core body temperature (CBT) via the continuous measure of the gastrointestinal temperature in participants with idiopathic hypersomnia (IH), non-specified hypersomnia (NSH) compared to healthy controls (HC) in a constant routine standardized bedrest (BR) protocol.

Methods: Consecutive participants evaluated in a National Reference Center for Rare Hypersomnias benefited from an extensive evaluation with one night polysomnography, followed by modified Multiple Sleep Latency Test (mMSLT), and a continuous 32-hour BR recording in standardized conditions. CBT was recorded via a telemetry pill (e-Celsius®) during the BR, modeled by a Cosinor, with extraction of MESOR, amplitude and phase. Participants with IH, diagnosed according to ICSD-3, were compared with participants with NSH (complaint of hypersomnolence but normal mMSLT and BR), and HC. Participants were divided in 4 groups based on their mMSLT mean sleep latency (mMSLT+,≤8min) and their BR total sleep time (BR+,≥19h).

Results: 108 participants (80% women, 28.3±7.8 y.o) were included in the analyses, 81 IH (83% women), 16 NSH (75% women), 11 HC (64% women). Cosinor amplitude and phase of CBT did not differ between IH, NSH and HC, nor in the subgroup analysis (37 BR+/mMSLT+, 35 BR+/mMSLT-, 9 BR-/mMSLT+, 27 BR-/mMSLT-). No difference in chronotypes was observed between groups. Women had a greater MESOR and reduced CBT amplitude compared to men.

Conclusion: The circadian rhythm of CBT showed no difference in amplitude or phase between IH, NSH and HC, and was not related to prolonged sleep time or objective daytime sleepiness.

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特发性嗜睡症患者核心体温昼夜节律的振幅和相位没有失调：病例对照研究

研究目的通过连续测量特发性嗜睡症（IH）和非特异性嗜睡症（NSH）患者的胃肠道温度，研究核心体温昼夜节律（CBT）的幅度和相位：方法：在国家罕见嗜睡症参考资料中心接受评估的连续参与者均接受了广泛的评估，包括一晚多导睡眠图检查、改良多重睡眠潜伏期测试（mMSLT）以及在标准化条件下连续 32 小时的卧床休息记录。通过遥测药片（e-Celsius®）记录 BR 期间的 CBT，并以 Cosinor 为模型，提取 MESOR、振幅和相位。根据 ICSD-3 诊断出的 IH 患者与 NSH（主诉嗜睡但 mMSLT 和 BR 正常）和 HC 患者进行了比较。根据参与者的mMSLT平均睡眠潜伏期（mMSLT+,≤8分钟）和BR总睡眠时间（BR+,≥19小时）将其分为4组：108名参与者（80%为女性，28.3±7.8岁）参与了分析，其中81名IH（83%为女性），16名NSH（75%为女性），11名HC（64%为女性）。CBT 的 Cosinor 振幅和相位在 IH、NSH 和 HC 之间没有差异，在亚组分析（37 BR+/mMSLT+、35 BR+/mMSLT-、9 BR-/mMSLT+、27 BR-/mMSLT-）中也没有差异。各组之间的时间型无差异。与男性相比，女性的 MESOR 更大，CBT 振幅更小：CBT的昼夜节律在IH、NSH和HC之间的振幅或相位没有差异，与睡眠时间延长或客观白天嗜睡无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep Medicine-Neurology (clinical)

CiteScore

8.70

自引率

10.70%

发文量

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