IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Systemic and ovarian impacts of heat stress in the porcine model.

IF 3.7 3区 生物学 Q1 DEVELOPMENTAL BIOLOGY
Reproduction Pub Date : 2024-11-11 Print Date: 2024-12-01 DOI:10.1530/REP-24-0217
Aileen F Keating, Jason W Ross, Lance H Baumgard
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Abstract

In brief: This review describes how heat stress causes systemic endocrine and metabolic alterations that contribute to intracellular ovarian perturbations, resulting in female infertility.

Abstract: Heat stress (HS) in mammals results from an imbalance in heat accumulation and dissipation. Fertility impairments consequential to HS have been recognized for decades in production animals, and more recently, observations have been extended to other species, including women. There are several systemic impacts of HS that can independently affect reproduction, including metabolic endotoxemia, reduced plane of nutrition, and endocrine disruption. At the level of the ovary, molecular pathways are altered by HS, such as inflammation, JAK-STAT, PI3K, oxidative stress, cell death, and heat shock response. Taken together, impaired ovarian function contributes to seasonal infertility that results from HS. This review paper describes the physiological and endocrine systemic impacts of HS that may independently and collaboratively impair fertility in the porcine model. The review then details ovarian intracellular events that are altered during HS and finally determines future needs in this area of research.

猪模型热应激对全身和卵巢的影响
哺乳动物的热应激(HS)是热量积累和散失失衡的结果。数十年来,人们已经认识到热应激对生产动物的生殖能力造成了损害,最近,人们还将观察范围扩大到包括女性在内的其他物种。HS 可对多个系统产生影响,包括代谢性内毒素血症、营养水平下降和内分泌紊乱,从而对生殖产生独立影响。在卵巢层面,HS 会改变分子通路,如炎症、JAK-STAT、PI3K、氧化应激、细胞死亡和热休克反应。综上所述,卵巢功能受损是HS导致季节性不孕的原因之一。本综述论文介绍了 HS 对生理和内分泌系统的影响,这些影响可能单独或共同损害猪模型的生育能力。然后,综述详细介绍了 HS 期间卵巢细胞内发生的变化,最后确定了这一研究领域的未来需求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Reproduction
Reproduction 生物-发育生物学
CiteScore
7.40
自引率
2.60%
发文量
199
审稿时长
4-8 weeks
期刊介绍: Reproduction is the official journal of the Society of Reproduction and Fertility (SRF). It was formed in 2001 when the Society merged its two journals, the Journal of Reproduction and Fertility and Reviews of Reproduction. Reproduction publishes original research articles and topical reviews on the subject of reproductive and developmental biology, and reproductive medicine. The journal will consider publication of high-quality meta-analyses; these should be submitted to the research papers category. The journal considers studies in humans and all animal species, and will publish clinical studies if they advance our understanding of the underlying causes and/or mechanisms of disease. Scientific excellence and broad interest to our readership are the most important criteria during the peer review process. The journal publishes articles that make a clear advance in the field, whether of mechanistic, descriptive or technical focus. Articles that substantiate new or controversial reports are welcomed if they are noteworthy and advance the field. Topics include, but are not limited to, reproductive immunology, reproductive toxicology, stem cells, environmental effects on reproductive potential and health (eg obesity), extracellular vesicles, fertility preservation and epigenetic effects on reproductive and developmental processes.
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