Navigating Dry Eye Research: A Comprehensive Review of Etiology, Clinical Trials, Patents, and Recent Advancements.

IF 1.4 Q4 PHARMACOLOGY & PHARMACY

Reviews on recent clinical trials Pub Date : 2024-10-09 DOI:10.2174/0115748871310261240929163138

Vindhya Pal, Sushma Verma

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引用次数: 0

Abstract

Background: Millions of people worldwide suffer from dry eye disease. Dry eye, a multifunctional condition of the ocular surface, typically occurs in conjunction with an unbalanced tear film. With increasing age, the dry eye problem becomes worse. Aqueous-deficit dry eye and evaporative dry eye are the two traditional classifications for dry eye. Various examination tools are used to diagnose dry eye. Clinical trials are conducted in four phases to check the safety and efficacy of drugs. The quick clearance from the precorneal space is ensured by the eye's advanced defense mechanism. It restricts the integrated medicine's entry into the eyes, resulting in a usually low bioavailability for topical eyedrops. In this study, we focus on recently developed formulations for curing dry eye.

Objective: This review's goal was to outline the etiology, clinical discovery and development, patents, and recent advancements for dry eye disease.

Results: The current study has described the widespread incidence of dry eye, which was found to be more common as people aged and recently developed formulations are treating dry eyes. According to research, novel formulations are enhancing ocular drug delivery.

Conclusion: In this review, etiology, clinical data, dry eye formulation patents, and recent advancements are all included.

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干眼症研究导航：全面回顾病因、临床试验、专利和最新进展。

背景：全世界有数百万人患有干眼症。干眼症是眼表的一种多功能疾病，通常与泪膜失衡同时发生。随着年龄的增长，干眼症会越来越严重。缺水性干眼症和蒸发性干眼症是干眼症的两种传统分类。诊断干眼症有多种检查工具。临床试验分四个阶段进行，以检查药物的安全性和有效性。眼球先进的防御机制确保了角膜前间隙的快速清除。它限制了综合药物进入眼睛，导致外用眼药水的生物利用度通常较低。在本研究中，我们将重点关注最近开发的用于治疗干眼症的配方：本综述旨在概述干眼症的病因、临床发现和发展、专利以及最新进展：目前的研究描述了干眼症的广泛发病率，发现随着年龄的增长，干眼症的发病率越来越高，最近开发的配方正在治疗干眼症。根据研究，新型配方正在加强眼部给药：本综述包括病因、临床数据、干眼症配方专利和最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reviews on recent clinical trials PHARMACOLOGY & PHARMACY-

CiteScore

3.10

自引率

5.30%

发文量

期刊介绍： Reviews on Recent Clinical Trials publishes frontier reviews on recent clinical trials of major importance. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: important Phase I – IV clinical trial studies, clinical investigations at all stages of development and therapeutics. The journal is essential reading for all researchers and clinicians involved in drug therapy and clinical trials.