Effects of photobiomodulation therapy for acute radiation dermatitis in patients with cancer: A systematic review and meta‑analysis of real-world evidence

IF 4.9 1区医学 Q1 ONCOLOGY

Radiotherapy and Oncology Pub Date : 2024-10-18 DOI:10.1016/j.radonc.2024.110589

Ying-Tong Lin , Kuang-Mou Tung , Jeng-Fong Chiou , Yen-Chao Chen , Wen-Hsuan Hou

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引用次数: 0

Abstract

Purpose

To examine the effectiveness of photobiomodulation therapy (PBMT) for acute radiation dermatitis (ARD) in patients with cancer.

Materials and methods

PubMed, Embase, Cochrane Library, and CINAHL were searched for articles published between database inception until July 2024. Randomized controlled trials (RCTs) and non-RCTs examining the effects of PBMT against ARD in patients with cancer were included for analysis. A random-effects model was used to conduct meta-analyses and sensitivity analyses. Subgroup analyses were conducted for cancer types and PBMT goals (prevention or treatment of ARD) with stratification for different grades of ARD.

Results

Eight studies (five RCTs and three non-RCTs) were included in this meta-analysis. Compared with the control group, the PBMT group exhibited significantly lower ARD incidence at grades 2 and 3 (risk difference = − 0.36, 95 % confidence interval = − 0.53 to − 0.19, I² = 85 %, P = < 0.00001). Subgroup analyses revealed that, compared with the control group, PBMT had a significant effect on both breast cancer and head and neck cancer. In addition, PBMT significantly reduced grades 2 and 3 ARD incidence in the PBMT group for both prevention and treatment subgroups.

Conclusion

PBMT may have beneficial effects on the prevention and treatment of higher-grade ARD in patients with breast cancer and head and neck cancer. Nevertheless, the studies included in this meta-analysis exhibited high heterogeneity. Therefore, the results must be interpreted with caution.

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光生物调节疗法治疗癌症患者急性放射性皮炎的效果：对真实世界证据的系统回顾和荟萃分析。

目的：研究光生物调节疗法（PBMT）对癌症患者急性放射性皮炎（ARD）的疗效：在 PubMed、Embase、Cochrane Library 和 CINAHL 中检索了自数据库建立至 2024 年 7 月期间发表的文章。纳入了研究PBMT对癌症患者ARD影响的随机对照试验（RCT）和非RCT进行分析。采用随机效应模型进行荟萃分析和敏感性分析。根据癌症类型和PBMT目标（预防或治疗ARD）进行了分组分析，并对不同等级的ARD进行了分层：本次荟萃分析共纳入八项研究（五项研究性试验和三项非研究性试验）。与对照组相比，PBMT 组的 2 级和 3 级 ARD 发生率明显降低（风险差异 = - 0.36，95 % 置信区间 = - 0.53 至 - 0.19，I2 = 85 %，P = < 0.00001）。分组分析显示，与对照组相比，PBMT 对乳腺癌和头颈部癌症都有显著效果。此外，在预防和治疗亚组中，PBMT 组的 2 级和 3 级 ARD 发生率均明显降低：结论：PBMT 可能对预防和治疗乳腺癌和头颈部癌症患者的高级别 ARD 有益。尽管如此，这项荟萃分析所纳入的研究显示出高度的异质性。因此，必须谨慎解读研究结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiotherapy and Oncology 医学-核医学

CiteScore

10.30

自引率

10.50%

发文量

2445

审稿时长

45 days

期刊介绍： Radiotherapy and Oncology publishes papers describing original research as well as review articles. It covers areas of interest relating to radiation oncology. This includes: clinical radiotherapy, combined modality treatment, translational studies, epidemiological outcomes, imaging, dosimetry, and radiation therapy planning, experimental work in radiobiology, chemobiology, hyperthermia and tumour biology, as well as data science in radiation oncology and physics aspects relevant to oncology.Papers on more general aspects of interest to the radiation oncologist including chemotherapy, surgery and immunology are also published.