Prediction of bone ingrowth into a porous novel hip-stem: A finite element analysis integrated with mechanoregulatory algorithm.

IF 1.7 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Tanmoy Loha, Kaushik Mukherjee, Bidyut Pal
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引用次数: 0

Abstract

Bone ingrowth into a porous implant is necessary for its long-term fixation. Although attempts have been made to quantify the peri-implant bone growth using finite element (FE) analysis integrated with mechanoregulatory algorithms, bone ingrowth into a porous cellular hip stem has scarcely been investigated. Using a three-dimensional (3D) FE model and mechanobiology-based numerical framework, the objective of this study was to predict the spatial distribution of evolutionary bone ingrowth into an uncemented novel porous hip stem proposed earlier by the authors. A CT-based FE macromodel of the implant-bone structure was developed. The bone material properties were assigned based on CT grey value. Peak musculoskeletal loading conditions, corresponding to level walking and stair climbing, were applied. The geometry of the implant-bone macromodel was divided into multiple submodels. A suitable mapping framework was used to transfer maximum nodal displacements from the FE macromodel to the cut boundaries of the FE submodels. CT grey value-based bone materials properties were assigned to the submodels. Thereafter, the submodels were solved and simulations of bone ingrowth were carried out using mechanoregulatory principle. A gradual increase in the average Young's modulus, from 1200 to 1500 MPa, of the bone tissue layer was observed considering all the submodels. The distal submodel exhibited 82% of bone ingrowth, whereas the proximal submodel experienced 65% bone ingrowth. Equilibrium in the bone ingrowth process was achieved in 7 weeks postoperatively, with a notable amount of bone ingrowth that should lead to biological fixation of the novel hip stem.

多孔新型髋关节干的骨生长预测:结合机械调节算法的有限元分析。
多孔植入物的长期固定需要骨生长。虽然已经有人尝试利用有限元(FE)分析和机械调节算法对植入物周围的骨生长进行量化,但对多孔细胞髋关节干内的骨生长却鲜有研究。本研究采用三维(3D)有限元模型和基于机械生物学的数值框架,目的是预测作者早先提出的非骨水泥新型多孔髋关节干的进化骨生长空间分布。研究开发了基于 CT 的植入物-骨结构 FE 宏模型。根据 CT 灰度值分配骨材料属性。应用了与平地行走和爬楼梯相对应的峰值肌肉骨骼负荷条件。植入物-骨宏观模型的几何形状被分为多个子模型。使用合适的映射框架将最大节点位移从 FE 宏模型转移到 FE 子模型的切割边界。将基于 CT 灰度值的骨材料属性分配给子模型。之后,对子模型进行求解,并利用机械调节原理对骨生长进行模拟。在所有子模型中,骨组织层的平均杨氏模量从 1200 兆帕逐渐增加到 1500 兆帕。远端子模型有 82% 的骨生长,而近端子模型则有 65% 的骨生长。骨生长过程在术后7周达到平衡,骨生长量显著增加,应能实现新型髋关节干的生物固定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.60
自引率
5.60%
发文量
122
审稿时长
6 months
期刊介绍: The Journal of Engineering in Medicine is an interdisciplinary journal encompassing all aspects of engineering in medicine. The Journal is a vital tool for maintaining an understanding of the newest techniques and research in medical engineering.
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