Effects of Ginseng Consumption on Cardiovascular Health Biomarkers in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL
Xiao-Feng Zhang, Rui-Xue Min, Zhen Wang, Yue Qi, Ruo-Nan Li, Jian-Ming Fan
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引用次数: 0

Abstract

Ginseng, with various pharmacological activities, has received increasing attention to improve cardiovascular health (CVH). Therefore, this meta-analysis synthesized the effect of ginseng consumption on biomarkers of CVH in adults. A systematic search was performed in the databases of PubMed, Scopus, Web of Science, Embase, and the Cochrane Library through July 24, 2023 to screen out English-language randomized controlled trials (RCTs) evaluating the effects of ginseng consumption on body composition, blood pressure, vascular stiffness, lipid metabolism, glucose metabolism, insulin resistance, inflammatory cytokines, and adipocytokines in adults. The weighted mean difference (WMD) and 95% confidence interval (CI) were used to evaluate the overall effect size, and STATA 12.0 was used for comprehensive analysis. Forty-five studies were included in the meta-analysis. Ginseng consumption significantly reduced systolic blood pressure (SBP) (WMD = -2.57 mmHg, 95% CI = -4.99 to -0.14, p = 0.038), total cholesterol (TC) (WMD = -4.40 mg/dL, 95% CI = -8.67 to -0.132, p = 0.043), low density lipoprotein cholesterol (LDL-C) (WMD = -2.81 mg/dL, 95% CI = -4.89 to -0.72, p = 0.008), C-reactive protein (CRP) (WMD = -0.41 mg/L, 95% CI = -0.73 to -0.10, p = 0.010), and interleukin-6 (IL-6) (WMD = -2.82 pg./mL, 95% CI = -4.31 to -1.32, p < 0.001). Subgroup analyses suggested that supplementation with ginseng for less than 12 weeks significantly reduced SBP, but 12 weeks or more improved TC and CRP. Ginseng consumption on SBP, TC, and CRP seemed to be more effective on unhealthy participants. The meta-analysis showed that ginseng consumption might have the potential to improve SBP, TC, LDL-C, CRP, and IL-6. These findings suggest that ginseng is a potential candidate for the maintenance of CVH. However, our results had high heterogeneity. Future high-quality studies are needed to firmly establish the clinical efficacy of ginseng consumption.

食用人参对成人心血管健康生物标志物的影响:随机对照试验的系统回顾和元分析》。
人参具有多种药理活性,在改善心血管健康(CVH)方面受到越来越多的关注。因此,本荟萃分析综述了服用人参对成人心血管健康生物标志物的影响。截至 2023 年 7 月 24 日,我们在 PubMed、Scopus、Web of Science、Embase 和 Cochrane Library 等数据库中进行了系统检索,以筛选出评估食用人参对成人身体成分、血压、血管僵硬度、脂代谢、糖代谢、胰岛素抵抗、炎症细胞因子和脂肪细胞因子影响的英文随机对照试验(RCT)。采用加权平均差 (WMD) 和 95% 置信区间 (CI) 评估总体效应大小,并使用 STATA 12.0 进行综合分析。荟萃分析共纳入了 45 项研究。服用人参可明显降低收缩压(SBP)(WMD = -2.57 mmHg,95% CI = -4.99 to -0.14,p = 0.038)、总胆固醇(TC)(WMD = -4.40 mg/dL,95% CI = -8.67 to -0.132,p = 0.043)、低密度脂蛋白胆固醇(LDL-C)(WMD = -2.81 mg/dL,95% CI = -4.89 to -0.72,p = 0.008)、C 反应蛋白 (CRP)(WMD = -0.41 mg/L,95% CI = -0.73 to -0.10,p = 0.010)和白细胞介素-6 (IL-6)(WMD = -2.82 pg./mL,95% CI = -4.31 to -1.32,p = 0.043)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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