LDH and NLR, as inflammatory markers, the independent risk factors for COVID-19 complicated with respiratory failure in elderly patients.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.12669/pjms.40.9.8728

Shan Wang, Jia Liu, Song Hu, Yongjun Mao

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引用次数: 0

Abstract

Objective: Lactate dehydrogenase (LDH) is an enzyme that is responsible for the production of lactic acid, which is a necessary byproduct when the body does not have enough oxygen. LDH levels in the blood can be used as a marker to predict mortality in patients with ARDS, severe COVID-19, and cancer. To analyze the clinical characteristics of COVID-19 in the elderly and the correlation between LDH and respiratory failure in COVID-19 patients, to improve the identification and management of this type of pneumonia by clinicians.

Methods: This was a single-center retrospective study. We performed routine laboratory tests in 105 COVID-19 patients admitted to the affiliated hospital of Qingdao University (Qingdao, China) from October 1, 2022 to February 1, 2023. The diagnosis of respiratory failure was established based on the results of blood gas analysis upon admission.

Results: The median age was 79 years. Among all univariable parameters, LDH, neutrophil to lymphocyte ratio (NLR) and Prothrombin Time (PT) were significantly independent risk factors of RF in elderly COVID-19 patients. LDH (AUC=0.829) also had a maximum specificity (96.5%), with the cutoff value of 280.5.

Conclusion: The levels of LDH, NLR, and PT may serve as potential indicators for elderly COVID-19 patients combined with respiratory failure. LDH, NLR and PT assays can be beneficial for patients who need closer respiratory monitoring and more aggressive supportive care to prevent a negative prognosis.

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LDH和NLR作为炎症标志物，是老年患者COVID-19并发呼吸衰竭的独立危险因素。

目的：乳酸脱氢酶（LDH）是一种负责产生乳酸的酶，乳酸是人体缺氧时产生的必要副产品。血液中的 LDH 水平可作为 ARDS、严重 COVID-19 和癌症患者的死亡率预测指标。目的：分析老年人 COVID-19 的临床特征以及 COVID-19 患者 LDH 与呼吸衰竭之间的相关性，以提高临床医生对此类肺炎的识别和处理能力：这是一项单中心回顾性研究。我们对青岛大学附属医院（中国青岛）2022年10月1日至2023年2月1日收治的105例COVID-19患者进行了常规实验室检查。根据入院时的血气分析结果确定呼吸衰竭的诊断：中位年龄为 79 岁。在所有单变量参数中，低密度脂蛋白胆固醇（LDH）、中性粒细胞与淋巴细胞比值（NLR）和凝血酶原时间（PT）是老年 COVID-19 患者发生呼吸衰竭的显著独立危险因素。LDH（AUC=0.829）的特异性最高（96.5%），其临界值为 280.5：结论：LDH、NLR 和 PT 的水平可作为老年 COVID-19 合并呼吸衰竭患者的潜在指标。LDH、NLR 和 PT 检测对需要更严密的呼吸监测和更积极的支持治疗以避免不良预后的患者有益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.