Correlation between neutrophil to lymphocyte ratio and C-reactive protein in diverse disease states in hospitalized patients.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.12669/pjms.40.9.8933

Ramsha Ghazal Arshad, Kaleem Ullah Toori

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Abstract

Objectives: This study aims to find if any significant correlation exists between C-reactive protein and Neutrophil to Lymphocyte Ratio as an indirect measure of inflammation.

Methods: We selected 983 patients with any inflammatory condition who presented to a tertiary care hospital and were admitted in medical wards or Intensive Care Units (ICUs) of KRL Hospital Islamabad from December 2021 to December 2022. The study was a cross sectional study and convenience sampling was done. The patients were categorized into five groups depending upon their pathophysiology. Kolmogorov Smirnov test was used to assess the normality of the data, and Spearman's coefficient was used to calculate the correlation between NLR and CRP.

Results: A total of 983 patients were included. Mean CRP and NLR levels were 89.9±3.2 and 7.06±0.24, respectively. There was a significant positive correlation between CRP-NLR in the infectious, non-infectious non-inflammatory, and malignancy groups (0.420, 0.381, 0.642, p <0.01), and inflammatory group (0.322, p <0.05), and no correlation with chronic diseases.

Conclusion: A significant correlation was shown to exist between CRP and NLR in patients with malignancies, non-infective non-inflammatory, inflammatory, and infective conditions and can therefore be used interchangeably to detect the presence of inflammation. Further exploration of these associations may contribute to a more nuanced understanding of the intricate relationships between different markers of inflammation and response to treatment.

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住院病人不同疾病状态下中性粒细胞与淋巴细胞比率和 C 反应蛋白之间的相关性。

研究目的本研究旨在找出 C 反应蛋白和中性粒细胞与淋巴细胞比值之间是否存在明显的相关性，以此作为炎症的间接测量指标：我们选择了 2021 年 12 月至 2022 年 12 月在伊斯兰堡 KRL 医院内科病房或重症监护室（ICU）就诊的 983 名炎症患者。本研究为横断面研究，采用方便抽样法。根据病理生理学将患者分为五组。采用 Kolmogorov Smirnov 检验评估数据的正态性，并采用斯皮尔曼系数计算 NLR 和 CRP 之间的相关性：结果：共纳入 983 例患者。CRP和NLR的平均水平分别为（89.9±3.2）和（7.06±0.24）。在感染组、非感染非炎症组和恶性肿瘤组中，CRP-NLR 之间存在明显的正相关性（0.420、0.381、0.642，p p 结论：在感染组、非感染非炎症组和恶性肿瘤组中，CRP-NLR 之间存在明显的正相关性（0.420、0.381、0.642，p p 结论）：在恶性肿瘤、非感染性非炎症、炎症和感染性疾病患者中，CRP 和 NLR 之间存在明显的相关性，因此可交替用于检测是否存在炎症。进一步探讨这些关联可能有助于更深入地了解不同炎症标志物与治疗反应之间错综复杂的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.