Treatment-Resistant Mood Disorders.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.12669/pjms.40.9.8245

Nadia Naeem, Rabia Farooqi

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引用次数: 0

Abstract

Objective: The objective of the study was to explore the presentation of symptoms in patients suffering from treatment-resistant mood disorder (TRMD), and associated clinical features, including age, gender, and comorbid conditions, that lead towards the development of treatment-resistant mood disorder. Furthermore, the study analyses the available psychotherapeutic treatment modalities and evidence-based non-medical treatment approaches for TRMD.

Method: The current study utilized a systematic review approach where 37 articles were studied and three articles were theoretically sampled to authenticate and signify the findings. PRISMA guidelines were followed and the review was conducted by searching social sciences databases and electronic libraries including Google Scholar, Sage Journal, and Science Direct (1990-2020).

Results: The results suggested that psychotherapeutic interventions including cognitive behavior therapy, mindful-based cognitive therapy; and interpersonal and social rhythm therapeutic interventions are efficacious modalities for treatment when in augmentation with psychopharmacological treatment. Bipolar diathesis and comorbid conditions of anxiety and personality disorders are possible causal factors in developing the condition of treatment resistance in mood disorders. The prevalence rate of TRMD is more common in females and in late adulthood. The analysis also suggests that there are numerous risk factors contributing to making a mood disorder treatment-resistant over a period of time; the most observed conditions were physical and psychological comorbidity, inaccurate diagnosis, lack of proper medical treatment, illness severity, and late age diagnosis. In evidence-based non-medical treatment approaches aerobics demonstrated promising results in improving the condition of complex mood disorders.

Conclusion: It was concluded that psychotherapeutic interventions in augmentation with pharmacological modalities enhance the efficacy of treatment.

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难治性情绪失调症。

研究目的本研究旨在探讨耐药情绪障碍（TRMD）患者的症状表现，以及导致耐药情绪障碍发生的相关临床特征，包括年龄、性别和合并症。此外，本研究还分析了针对 TRMD 的现有心理治疗模式和循证非药物治疗方法：本研究采用了系统性综述的方法，共研究了 37 篇文章，并从理论上抽取了 3 篇文章来验证和标明研究结果。研究遵循 PRISMA 准则，通过搜索社会科学数据库和电子图书馆（包括 Google Scholar、Sage Journal 和 Science Direct，1990-2020 年）进行综述：结果表明，心理治疗干预包括认知行为疗法、正念认知疗法以及人际和社会节奏治疗干预，在与精神药物治疗相结合时是有效的治疗方式。双相情感障碍以及焦虑症和人格障碍的合并症可能是导致情绪障碍患者出现治疗抵抗的原因。TRMD的发病率在女性和成年晚期更为常见。分析还表明，有许多风险因素会导致情绪障碍在一段时间内产生抗药性；观察到最多的情况是身体和心理并发症、诊断不准确、缺乏适当的医疗、疾病严重程度和诊断年龄过晚。在以证据为基础的非药物治疗方法中，有氧运动在改善复杂情绪障碍的病情方面表现出了良好的效果：结论：心理治疗干预与药物治疗相结合，可提高治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.