Alpha transcranial alternating current stimulation modulates pain anticipation and perception in a context-dependent manner.

IF 5.9 1区 医学 Q1 ANESTHESIOLOGY
PAIN® Pub Date : 2025-05-01 Epub Date: 2024-10-16 DOI:10.1097/j.pain.0000000000003452
Xiaoyun Li, Richu Jin, Xuejing Lu, Yilin Zhan, Naifu Jiang, Weiwei Peng
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Abstract

Abstract: Pain perception is closely tied to the brain's anticipatory processes, particularly involving the suppression of sensorimotor α-oscillations, which reflect the system's readiness for incoming pain. Higher sensorimotor α-oscillation levels are correlated with lower pain sensitivity. Alpha transcranial alternating current stimulation (α-tACS) can enhance these oscillations, potentially reducing pain perception, with effects that may be sustained and influenced by the certainty of pain expectations. Hence, this study investigated the immediate and sustained effects of α-tACS on pain anticipation and perception, focusing on how these effects are shaped by the certainty of expectations. In a double-blind, sham-controlled design, 80 healthy participants underwent a 20-minute session of real or sham α-tACS over the right sensorimotor region. Behavioral and neural responses related to pain anticipation and perception were recorded before, immediately after, and 30 minutes poststimulation under both certain and uncertain conditions. Compared with sham stimulation, real α-tACS disrupted the habituation of laser-evoked potentials (N2-P2 complex), particularly under certain expectations, with effects persisting 30 minutes poststimulation. In anticipatory brain oscillations, real α-tACS enhanced somatosensory α1-oscillations and increased midfrontal θ-oscillations in conditions of certainty, with θ-oscillation modulation showing sustained effects. Mediation analysis revealed that α-tACS reduced pain reactivity by enhancing somatosensory α1-oscillations but increased pain reactivity through the enhancement of midfrontal θ-oscillations, with the latter effect being more pronounced. These findings suggest that while α-tACS may provide pain relief through somatosensory α-oscillation augmentation, its stronger and longer-lasting impact on midfrontal θ-oscillations could lead to hyperalgesia, particularly in the context of certain pain expectations.

α经颅交变电流刺激以一种依赖于情境的方式调节疼痛的预期和感知。
摘要:疼痛感知与大脑的预期过程密切相关,特别是涉及到感觉运动α-振荡的抑制,它反映了系统对传入疼痛的准备状态。较高的感觉运动 α 振荡水平与较低的疼痛敏感性相关。α经颅交变电流刺激(α-tACS)可增强这些振荡,从而降低疼痛感,其效果可能会持续,并受疼痛预期确定性的影响。因此,本研究调查了α-tACS对疼痛预期和感知的直接和持续影响,重点研究了这些影响是如何受预期的确定性影响的。在双盲、假对照设计中,80 名健康参与者在右侧感觉运动区接受了 20 分钟的真实或假 α-tACS 治疗。在确定和不确定条件下,分别记录了刺激前、刺激后和刺激后 30 分钟内与疼痛预期和感知有关的行为和神经反应。与假刺激相比,真实α-tACS干扰了激光诱发电位(N2-P2复合体)的习惯化,尤其是在确定的预期条件下,其影响在刺激后30分钟仍持续存在。在预期脑振荡中,真实α-tACS增强了躯体感觉α1-振荡,并在确定性条件下增加了中额叶θ-振荡,其中θ-振荡调节显示出持续效应。中介分析显示,α-tACS 通过增强躯体感觉α1-振荡来降低疼痛反应性,但通过增强中额叶θ-振荡来提高疼痛反应性,后者的效果更为明显。这些研究结果表明,虽然α-tACS可通过增强体感α-振荡来缓解疼痛,但它对中额叶θ-振荡的影响更强、更持久,可能会导致痛觉亢进,尤其是在某些疼痛预期的情况下。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
PAIN®
PAIN® 医学-临床神经学
CiteScore
12.50
自引率
8.10%
发文量
242
审稿时长
9 months
期刊介绍: PAIN® is the official publication of the International Association for the Study of Pain and publishes original research on the nature,mechanisms and treatment of pain.PAIN® provides a forum for the dissemination of research in the basic and clinical sciences of multidisciplinary interest.
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